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dc.contributor.authorCahusac, Peter-
dc.contributor.editorPaley, Benjamin F-
dc.contributor.editorWarfield, Tomas E-
dc.description.abstractMany cellular elements of the skin appear to involve glutamate for signalling. This has been most extensively studied in nociceptive nerve endings (supplied by C and Aδ fibres). Both ionotropic and metabotropic glutamate receptors are involved in inflammation, and modulate hyperalgesia and allodynia. Less work has been on low threshold mechanoreceptors in the skin (supplied by Aβ fibres), although there is clear evidence for a modulatory role here too. There is evidence that other structural cellular elements, such as keratinocytes use glutamate for signaling, and may be important for skin growth and wound healing. Finally, excessive release of glutamate and/or aberrant expression of metabotropic glutamate receptors may be contributory factors in the development of skin melanomas. There appears to be significant clinical potential in the development of topically applied glutamate receptor active compounds to treat a range of different skin disorderen_UK
dc.publisherNova Science Publishers-
dc.relationCahusac P (2008) Glutamate Signalling in the Skin. In: Paley Benjamin F, Warfield Tomas E (ed.). Amino Acid Receptor Research, New York: Nova Science Publishers, pp. 119-131.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.-
dc.subject.lcshGlutamic acid Receptors-
dc.titleGlutamate Signalling in the Skinen_UK
dc.typePart of book or chapter of booken_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.type.statusBook Chapter: publisher version-
dc.citation.btitleAmino Acid Receptor Research-
dc.publisher.addressNew York-
Appears in Collections:Psychology Book Chapters and Sections

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