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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Hepatitis C in a new therapeutic era: Recontextualising the lived experience
Author(s): Whiteley, David
Whittaker, Anne
Elliott, Lawrie
Cunningham-Burley, Sarah
Keywords: direct‐acting antivirals
hepatitis C
interferon‐free treatment
lived experience
social phenomenology
thematic analysis
treatment rationing
Issue Date: 31-Jul-2018
Date Deposited: 10-Dec-2018
Citation: Whiteley D, Whittaker A, Elliott L & Cunningham-Burley S (2018) Hepatitis C in a new therapeutic era: Recontextualising the lived experience. Journal of Clinical Nursing, 27 (13-14), pp. 2729-2739.
Abstract: Aims and objectives To explore the experience of adults living with hepatitis C in a new era of interferon‐free treatment. Background Hepatitis C is a leading cause of morbidity and mortality worldwide, posing a significant challenge to global public health. Historically, the treatment of hepatitis C was poorly efficacious and highly demanding; however, more effective and tolerable therapies have become available in high‐income nations in recent years. This is the first study to explore how these significant developments in the treatment of hepatitis C may have influenced the experience of those living with the virus, and their understanding of the disease. Design A qualitative study underpinned by social phenomenological theory. Methods Data were generated through semi‐structured interviews with a purposive sample of 20 hepatitis C positive adults living in a large city in Scotland. Results Thematic analysis identified three overriding themes. “Positioning hepatitis C” illustrated how the disease was understood within wider sociocultural, medical and politico‐economic contexts. “Beyond a physical burden” emphasised the emotional aspect of infection, and “a new uncertainty” revealed participants’ cautious response to the advances in hepatitis C therapy. Conclusions Interthematic discourse portrayed the new era of hepatitis C treatment as holding little sway over constructions of the illness, as narratives resonated with previous studies. Such unmoving “lay” understandings of hepatitis C may pose potential barriers to the new therapeutic era from reaching its full potential. Relevance to clinical practice How people living with the virus perceive and understand hepatitis C can have an adverse impact on their engagement with care and treatment. Whilst global medical discourse eulogises the arrival of a new era of therapy, there remain significant challenges for nurses engaging those with hepatitis C in therapeutic pathways.
DOI Link: 10.1111/jocn.14083
Rights: This is the peer reviewed version of the following article: Whiteley D, Whittaker A, Elliott L, Cunningham‐Burley S. Hepatitis C in a new therapeutic era: Recontextualising the lived experience. J Clin Nurs. 2018;27:2729–2739, which has been published in final form at This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

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