Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/28322
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The Highest Mountain: T-Cell Technology
Author(s): McIntosh, Bryan
Fascia, Michael
Keywords: Cancer
Leukaemia
T-cells
Immunosuppression
T-cell receptor
TCR
Issue Date: 31-Dec-2014
Citation: McIntosh B & Fascia M (2014) The Highest Mountain: T-Cell Technology. British Journal of Healthcare Management, 20 (6), pp. 281-285. https://doi.org/10.12968/bjhc.2014.20.6.281.
Abstract: T-lymphocytes (T-cell) therapy offers a treatment for cancers. Developing this technology in the future provides the opportunity to revolutionise treatment and to make cancer a chronic condition. T-cells in themselves are a type of lymphocytes (itself a type of white blood cell) that play a central role in cell mediated immunity. They can be distinguished from other lymphocytes, such as B-cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. T-cells have the capacity to destroy diseased cells, but tumours present a considerable challenge that reduces their impact. As cancer cells are frequently ‘invisible’ to the immune system, and they create an environment that suppresses T-cell activity., genetic engineering of T-cells can be used therapeutically to overcome these challenges. T-cells can be taken from the blood of cancer patients and then modified to recognise and destroy cancer-specific antigens.
DOI Link: 10.12968/bjhc.2014.20.6.281
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in British Journal of Healthcare Management, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.12968/bjhc.2014.20.6.281

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