Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The Highest Mountain: T-Cell Technology
Author(s): McIntosh, Bryan
Fascia, Michael
Keywords: Cancer
T-cell receptor
Issue Date: 31-Dec-2014
Citation: McIntosh B & Fascia M (2014) The Highest Mountain: T-Cell Technology. British Journal of Healthcare Management, 20 (6), pp. 281-285.
Abstract: T-lymphocytes (T-cell) therapy offers a treatment for cancers. Developing this technology in the future provides the opportunity to revolutionise treatment and to make cancer a chronic condition. T-cells in themselves are a type of lymphocytes (itself a type of white blood cell) that play a central role in cell mediated immunity. They can be distinguished from other lymphocytes, such as B-cells and natural killer cells (NK cells), by the presence of a T-cell receptor (TCR) on the cell surface. T-cells have the capacity to destroy diseased cells, but tumours present a considerable challenge that reduces their impact. As cancer cells are frequently ‘invisible’ to the immune system, and they create an environment that suppresses T-cell activity., genetic engineering of T-cells can be used therapeutically to overcome these challenges. T-cells can be taken from the blood of cancer patients and then modified to recognise and destroy cancer-specific antigens.
DOI Link: 10.12968/bjhc.2014.20.6.281
Rights: This document is the Accepted Manuscript version of a Published Work that appeared in final form in British Journal of Healthcare Management, copyright © MA Healthcare, after peer review and technical editing by the publisher. To access the final edited and published work see

Files in This Item:
File Description SizeFormat 
76944737.pdfFulltext - Accepted Version245.29 kBAdobe PDFView/Open

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.