Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27686
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dc.contributor.authorEdinburgh, Robert Men_UK
dc.contributor.authorHengist, Aaronen_UK
dc.contributor.authorSmith, Harry Aen_UK
dc.contributor.authorTravers, Rebecca Len_UK
dc.contributor.authorKoumanov, Francoiseen_UK
dc.contributor.authorBetts, James Aen_UK
dc.contributor.authorThompson, Dylanen_UK
dc.contributor.authorWalhin, Jean-Philippeen_UK
dc.contributor.authorWallis, Gareth Aen_UK
dc.contributor.authorHamilton, D Leeen_UK
dc.contributor.authorStevenson, Emma Jen_UK
dc.contributor.authorTipton, Kevin Den_UK
dc.contributor.authorGonzalez, Javier Ten_UK
dc.date.accessioned2018-08-24T14:28:22Z-
dc.date.available2018-08-24T14:28:22Z-
dc.date.issued2018-11en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27686-
dc.description.abstractAims To characterize postprandial glucose flux after exercise in the fed versus overnight fasted-state and to investigate potential underlying mechanisms. Methods In a randomized order, twelve men underwent breakfast-rest (BR; 3 h semi-recumbent), breakfast-exercise (BE; 2 h semi-recumbent before 60-min of cycling (50% peak power output) and overnight fasted-exercise (FE; as per BE omitting breakfast) trials. An oral glucose tolerance test (OGTT) was completed post-exercise (post-rest on BR). Dual stable isotope tracers ([U-13C] glucose ingestion and [6,6-2H2] glucose infusion) and muscle biopsies were combined to assess postprandial plasma glucose kinetics and intramuscular signaling, respectively. Plasma intestinal fatty acid binding (I-FABP) concentrations were determined as a marker of intestinal damage. Results Breakfast before exercise increased post-exercise plasma glucose disposal rates during the OGTT, from 44 g•120 min-1 in FE [35 to 53 g•120 min-1] (mean [normalized 95% CI]) to 73 g•120 min-1 in BE [55 to 90 g•120 min-1; p = 0.01]. This higher plasma glucose disposal rate was, however, offset by increased plasma glucose appearance rates (principally OGTT-derived), resulting in a glycemic response that did not differ between BE and FE (p = 0.11). Plasma I-FABP concentrations during exercise were 264 pg•mL-1 [196 to 332 pg•mL-1] lower in BE versus FE (p = 0.01). Conclusion Breakfast before exercise increases post-exercise postprandial plasma glucose disposal, which is offset (primarily) by increased appearance rates of orally-ingested glucose. Therefore, metabolic responses to fed-state exercise cannot be readily inferred from studies conducted in a fasted state.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Physiological Societyen_UK
dc.relationEdinburgh RM, Hengist A, Smith HA, Travers RL, Koumanov F, Betts JA, Thompson D, Walhin J, Wallis GA, Hamilton DL, Stevenson EJ, Tipton KD & Gonzalez JT (2018) Preexercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Men. American Journal of Physiology-Endocrinology and Metabolism, 315 (5), pp. E1062-E1074. https://doi.org/10.1152/ajpendo.00163.2018en_UK
dc.rightsLicensed under Creative Commons Attribution CC-BY 4.0 (https://creativecommons.org/licenses/by/4.0/): © the American Physiological Society.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectPhysiology (medical)en_UK
dc.subjectPhysiologyen_UK
dc.subjectEndocrinology, Diabetes and Metabolismen_UK
dc.titlePreexercise Breakfast Ingestion versus Extended Overnight Fasting Increases Postprandial Glucose Flux after Exercise in Healthy Menen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2019-08-15en_UK
dc.identifier.doi10.1152/ajpendo.00163.2018en_UK
dc.identifier.pmid30106621en_UK
dc.citation.jtitleAmerican journal of physiology. Endocrinology and metabolismen_UK
dc.citation.issn1522-1555en_UK
dc.citation.issn0193-1849en_UK
dc.citation.volume315en_UK
dc.citation.issue5en_UK
dc.citation.spageE1062en_UK
dc.citation.epageE1074en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.funderMedical Research Councilen_UK
dc.author.emailk.d.tipton@stir.ac.uken_UK
dc.citation.date14/08/2018en_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationNewcastle Universityen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Bathen_UK
dc.identifier.isiWOS:000451048700028en_UK
dc.identifier.scopusid2-s2.0-85055486996en_UK
dc.identifier.wtid983067en_UK
dc.contributor.orcid0000-0002-5620-4788en_UK
dc.contributor.orcid0000-0002-6545-8122en_UK
dc.date.accepted2018-08-02en_UK
dc.date.filedepositdate2018-08-24en_UK
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