Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/27140
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dc.contributor.authorGillies, Katieen_UK
dc.contributor.authorBower, Peteren_UK
dc.contributor.authorElliott, Jimen_UK
dc.contributor.authorMacLennan, Graemeen_UK
dc.contributor.authorNewlands, Rumanaen_UK
dc.contributor.authorOgden, Margareten_UK
dc.contributor.authorTreweek, Shaunen_UK
dc.contributor.authorWells, Maryen_UK
dc.contributor.authorWitham, Miles Den_UK
dc.contributor.authorYoung, Bridgeten_UK
dc.contributor.authorFrancis, Jill Jen_UK
dc.date.accessioned2018-04-27T22:59:03Z-
dc.date.available2018-04-27T22:59:03Z-
dc.date.issued2018-03-27en_UK
dc.identifier.other197en_UK
dc.identifier.urihttp://hdl.handle.net/1893/27140-
dc.description.abstractBackground  Non-retention of participants seriously affects the credibility of clinical trial results and significantly reduces the potential of a trial to influence clinical practice. Non-retention can be defined as instances where participants leave the study prematurely. Examples include withdrawal of consent and loss to follow-up and thus outcome data cannot be obtained. The majority of existing interventions targeting retention fail to describe any theoretical basis for the observed improvement, or lack of improvement. Moreover, most of these interventions lack involvement of participants in their conception and/or design, raising questions about their relevance and acceptability. Many of the causes of non-retention involve people performing a behaviour (e.g. not returning a questionnaire). Behaviour change is difficult, and the importance of a strong theoretical basis for interventions that aim to change behaviour is increasingly recognised. This research aims to develop and pilot theoretically informed, participant-centred, evidence-based behaviour change interventions to improve retention in trials.  Methods  This research will generate data through semi-structured interviews on stakeholders’ perspectives of the reasons for trial non-retention. It will identify perceived barriers and enablers to trial retention using the Theoretical Domains Framework. The intervention development work will involve identification of behaviour change techniques, using recognised methodology, and co-production of retention interventions through discussion groups with end-users. An evaluation of intervention acceptability and feasibility will be conducted in focus groups. Finally, a ready-to-use evaluation framework to deploy in Studies Within A Trial as well as an explanatory retention framework will be developed for identifying and tackling modifiable issues to improve trial retention.  Discussion  We believe this to be one of the first studies to apply a theoretical lens to the development of interventions to improve trial retention that have been informed by, and are embedded within, participants’ experiential accounts. By developing and identifying priority interventions this study will support efforts to reduce research waste.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.relationGillies K, Bower P, Elliott J, MacLennan G, Newlands R, Ogden M, Treweek S, Wells M, Witham MD, Young B & Francis JJ (2018) Systematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocol. Trials, 19 (1), Art. No.: 197. https://doi.org/10.1186/s13063-018-2572-0en_UK
dc.rights© The Author(s). 2018 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectTrialsen_UK
dc.subjectRetentionen_UK
dc.subjectNon-retentionen_UK
dc.subjectDropoutl Theoryen_UK
dc.subjectInterventionen_UK
dc.subjectInterviewsen_UK
dc.titleSystematic Techniques to Enhance rEtention in Randomised controlled trials: the STEER study protocolen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/s13063-018-2572-0en_UK
dc.identifier.pmid29580260en_UK
dc.citation.jtitleTrialsen_UK
dc.citation.issn1745-6215en_UK
dc.citation.volume19en_UK
dc.citation.issue1en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.citation.date27/03/2018en_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Manchesteren_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationCity University Londonen_UK
dc.identifier.isiWOS:000428895100002en_UK
dc.identifier.scopusid2-s2.0-85045283906en_UK
dc.identifier.wtid876686en_UK
dc.contributor.orcid0000-0001-5789-2773en_UK
dc.date.accepted2018-02-22en_UK
dc.date.filedepositdate2018-04-27en_UK
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