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dc.contributor.authorPaudyal, Priyamvadaen_UK
dc.contributor.authorSemple, Seanen_UK
dc.contributor.authorGaihre, Santoshen_UK
dc.contributor.authorSteiner, Markus FCen_UK
dc.contributor.authorNiven, Roben_UK
dc.contributor.authorAyres, Jon Gen_UK
dc.description.abstractObjectives: Inhalation of a cotton-based particulates has previously been associated with respiratory symptoms and impaired lung function. This study investigates the respiratory health of Nepalese textile workers in relation to dust and endotoxin exposure.  Methods: A total of 938 individuals from four sectors (garment, carpet, weaving and recycling) of the textile industry in Kathmandu, Nepal completed a health questionnaire and performed spirometry. A subset (n=384) performed cross-shift spirometry. Personal exposure to inhalable dust and airborne endotoxin was measured during a full shift for 114 workers.  Results: The overall prevalence of persistent cough, persistent phlegm, wheeze ever, breathlessness ever and chest tightness ever was 8.5%, 12.5%, 3.2%, 6.5% and 12.3%, respectively. Symptoms were most common among recyclers and least common among garment workers. Exposure to inhalable dust significantly predicted persistent cough and chest tightness. Exposure to endotoxin did not have any independent predictive effect. Significant cross-shift reduction in forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) were found (p<0.001 for both) being largest for FEV1 in the recyclers (-143 mL), and least in the garment workers (-38 mL; p=0.012). Exposure to inhalable dust predicted a cross-shift reduction in FEV1.  Conclusions: This study is the first to investigate the respiratory health of Nepalese cotton workers. The measured association between inhalable dust exposure and reporting of respiratory symptoms and across-shift decrement in FEV1 and FVC indicates that improved dust control measures should be instituted, particularly in the recycling and carpet sectors. The possible role of other biologically active agents of cotton dust beyond endotoxin should be further explored.en_UK
dc.publisherBMJ Publishing Groupen_UK
dc.relationPaudyal P, Semple S, Gaihre S, Steiner MF, Niven R & Ayres JG (2015) Respiratory symptoms and cross-shift lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal: A cross-sectional study. Occupational and Environmental Medicine, 72 (12), pp. 870-876.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleRespiratory symptoms and cross-shift lung function in relation to cotton dust and endotoxin exposure in textile workers in Nepal: A cross-sectional studyen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Paudyal et al.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleOccupational and Environmental Medicineen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationBrighton and Sussex Medical Schoolen_UK
dc.contributor.affiliationInstitute for Social Marketingen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Manchesteren_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorPaudyal, Priyamvada|en_UK
local.rioxx.authorSemple, Sean|0000-0002-0462-7295en_UK
local.rioxx.authorGaihre, Santosh|en_UK
local.rioxx.authorSteiner, Markus FC|en_UK
local.rioxx.authorNiven, Rob|en_UK
local.rioxx.authorAyres, Jon G|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenamePaudyal et al.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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