STORRE

Many approaches for approximate metric search rely on a permutation-based representation of the original data objects. The main advantage of transforming metric objects into permutations is that the latter can be efficiently indexed and searched using data structures such as inverted-files and prefix trees. Typically, the permutation is obtained by ordering the identifiers of a set of pivots according to their distances to the object to be represented. In this paper, we present a novel approa...

Although the neural mechanism supporting episodic recollection has been well characterized in younger adults, exactly how recollection is supported in older adults remains unclear. The electrophysiological correlate of recollection-the parietal retrieval success effect-for example, has been shown to be sensitive to both the amount of information recollected and the accuracy of remembered information in younger adults. To date, there is mixed evidence that parietal effect also scales with the ...

Background: Uptake in the national colorectal cancer screening programme in England varies by socioeconomic status. We assessed four interventions aimed at reducing this gradient, with the intention of improving the health benefits of screening. Methods: All people eligible for screening (men and women aged 60–74 years) across England were included in four cluster-randomised trials. Randomisation was based on day of invitation. Each trial compared the standard information with the standard in...

Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors that belong to the nuclear hormone receptor superfamily. Three PPARs (PPARα, PPARβ and PPARγ) exist in mammals, and all are activated by binding lipid molecules, including fatty acids and their derivatives, and also by synthetic drug ligands. Together, these three receptors are critical regulators of lipid and energy homeostasis in mammals. PPARγ is a central factor in fat uptake and storage and is ...