Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/26609
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dc.contributor.advisorAdams, Alexandra-
dc.contributor.advisorMigaud, Herve-
dc.contributor.advisorTaylor, John F-
dc.contributor.authorChalmers, Lynn-
dc.date.accessioned2018-02-02T08:46:24Z-
dc.date.issued2017-08-30-
dc.identifier.citationChalmers, L., Thompson, K. D., Taylor, J. F., Black, S., Migaud, H., North, B. and Adams, A. (2016). A comparison of the response of diploid and triploid Atlantic salmon (Salmo salar) siblings to a commercial furunculosis vaccine and subsequent experimental infection with Aeromonas salmonicida. Fish & Shellfish Immunology, 57, 301–308. http://dx.doi.org/10.1016/j.fsi.2016.08.049en_GB
dc.identifier.citationChalmers, L., Taylor, J. F., Roy, W., Preston, A. C., Migaud, H. and Adams, A. (2017). A comparison of disease susceptibility and innate immune response between diploid and triploid Atlantic salmon (Salmo salar) siblings following experimental infection with Neoparamoeba perurans, causative agent of amoebic gill disease. Parasitology, 144 (9), 1229–1242. http://dx.doi.org/10.1017/S0031182017000622en_GB
dc.identifier.urihttp://hdl.handle.net/1893/26609-
dc.description.abstractSterile triploid Atlantic salmon represent a solution to the issues of pre-harvest sexual maturation and mature escapees from open aquaculture systems. Although the initial problems of reduced performance and increased deformities in triploids have been thoroughly researched, there is a continued lack of information on their susceptibility and response to disease and routine on-farm treatments compared to diploids. Thus, the main aim of this thesis was to enhance the current understanding of triploid health and immunity through experimental disease challenges and treatments, and aid in determining their robustness and, therefore, suitability for aquaculture. A commercial furunculosis vaccine equally protected diploids and triploids against challenge with Aeromonas salmonicida, and adhesion scores were similar between ploidy (Chapter 2). Interestingly, triploids had lower white blood cell counts but increased cellular activity, e.g. respiratory burst, compared to diploids. Following experimental cohabitation infection with Neoparamoeba perurans, causative agent of Amoebic Gill Disease (AGD), ploidy did not affect the manifestation or severity of AGD-associated gill pathology, or the serum innate immune response (Chapter 3). Hydrogen peroxide, used to treat against parasitic diseases, elicited similar primary and secondary stress responses in both ploidy, but led to differences in the expression of stress (cat, gpx1, gr, hsp70, sod1, sod2) and immune (saa5, crp/sap1a, crp/sap1b, il1β) genes (Chapter 4). Finally, vaccination with different vaccine treatments (4 commercial vaccines, 6 different vaccine combinations and a sham-vaccinated control) showed no ploidy differences in adhesion score or antibody response, although vertebral deformities remained higher in triploids (Chapter 5). Increasing severity of vaccine treatments negatively affected weight, length and thermal growth coefficient in both ploidy. Triploids were heavier than diploids at smolt (+ 14 %) and post smolt (+ 32 %). Overall, this research shows that triploid Atlantic salmon respond as well as diploids to disease and treatment challenges, and supports their application into full-scale commercial aquaculture.en_GB
dc.language.isoenen_GB
dc.publisherUniversity of Stirlingen_GB
dc.relation.urihttp://hdl.handle.net/1893/24317-
dc.relation.urihttp://hdl.handle.net/1893/25400-
dc.rightsRights for the copy of the paper included in this thesis: Chalmers L, Thompson K, Taylor J, Black S, Migaud H, North B & Adams A (2016) A comparison of the response of diploid and triploid Atlantic salmon (Salmo salar) siblings to a commercial furunculosis vaccine and subsequent experimental infection with Aeromonas salmonicida, Fish and Shellfish Immunology, 57, pp. 301-308. http://dx.doi.org/10.1016/j.fsi.2016.08.049 © 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).-
dc.rightsRights for the copy of the paper included in this thesis: Chalmers, L., Taylor, J. F., Roy, W., Preston, A. C., Migaud, H. and Adams, A. (2017). A comparison of disease susceptibility and innate immune response between diploid and triploid Atlantic salmon (Salmo salar) siblings following experimental infection with Neoparamoeba perurans, causative agent of amoebic gill disease. Parasitology, 144 (9), 1229–1242. http://dx.doi.org/10.1017/S0031182017000622 COPYRIGHT: © Cambridge University Press 2017 This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.-
dc.subjectAtlantic salmonen_GB
dc.subjectTriploiden_GB
dc.subjectImmunityen_GB
dc.subjectDisease Challengeen_GB
dc.subjectVaccinationen_GB
dc.subject.lcshAtlantic salmonen_GB
dc.subject.lcshFishes Diseasesen_GB
dc.titleA comparative assessment of health and immune response between triploid and diploid Atlantic salmon (Salmo salar)en_GB
dc.typeThesis or Dissertationen_GB
dc.type.qualificationlevelDoctoralen_GB
dc.type.qualificationnameDoctor of Philosophyen_GB
dc.rights.embargodate2020-02-01-
dc.rights.embargoreasonAt the request of the author the thesis has been embargoed for 24 months on the grounds of a Commercial and Publication Exception to the UKRI required 12 month maximum. UKRI have agreed that, at the discretion of the University, authors can request a short extension up to a further year beyond this 12 months. Only in very exceptional rare circumstances can a thesis be placed under an embargo longer than a total of 24 months.en_GB
dc.contributor.funderINNOVATE UK/BBSRC Grant Award BB/M012049/1: Optimisation and implementation of sterile triploid salmon in Scotland. Project in collaboration with Pharmaq, Marine Harvest and Biomaren_GB
dc.author.emaillchalmers3@hotmail.co.uken_GB
dc.rights.embargoterms2020-02-02en_GB
dc.rights.embargoliftdate2020-02-02-
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