|dc.contributor.author||Sweeney, Emma L||-|
|dc.contributor.author||Hamilton, David Lee||-|
|dc.description.abstract||Sleep restriction is associated with impaired glucose metabolism and insulin resistance, however, the underlying mechanisms leading to this impairment are unknown. This study aimed to assess whether the decrease in insulin sensitivity observed after sleep restriction is accompanied by changes in skeletal muscle PKB activity. Ten healthy young males participated in this randomized crossover study which included two conditions separated by a 3‐week washout period. Participants underwent two nights of habitual sleep (CON) and two nights of sleep which was restricted to 50% of habitual sleep duration (SR) in the home environment. Whole‐body glucose tolerance and insulin sensitivity were assessed by an oral glucose tolerance test after the second night of each condition. Skeletal muscle tissue samples were obtained from the vastus lateralis to determine PKB activity. Findings displayed no effect of trial on plasma glucose concentrations (P = 0.222). Plasma insulin area under the curve was higher after sleep restriction compared to the control (P = 0.013). Matsuda index was 18.6% lower in the sleep restriction (P = 0.010). Fold change in PKB activity from baseline tended to be lower in the sleep restriction condition at 30 min (P = 0.098) and 120 min (P = 0.087). In conclusion, we demonstrated decreased whole‐body insulin sensitivity in healthy young males following two nights of sleep restriction. Skeletal muscle insulin signaling findings are inconclusive and require further study to examine any potential changes.||en_UK|
|dc.publisher||American Physiological Society||-|
|dc.relation||Sweeney EL, Jeromson S, Hamilton DL, Brooks N & Walshe I (2017) Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males, Physiological Reports, 5 (23), Art. No.: e13498.||-|
|dc.rights||© 2017 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of The Physiological Society and the American Physiological Society This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.||-|
|dc.subject||peripheral insulin signaling||en_UK|
|dc.title||Skeletal muscle insulin signaling and whole-body glucose metabolism following acute sleep restriction in healthy males||en_UK|
|dc.type.status||Publisher version (final published refereed version)||-|
|dc.contributor.affiliation||University of Stirling||-|
|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
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