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dc.contributor.authorAlbalat, Amaya-
dc.contributor.authorMullen, William-
dc.contributor.authorHusi, Holger-
dc.contributor.authorMischak, Harald-
dc.contributor.editorTouyz, RM-
dc.contributor.editorSchiffrin, EL-
dc.description.abstractIn vascular diseases, as in many other pathophysiological conditions, tissue proteins are subjected to a number of different changes such as protein expression, posttranslational modifications, and proteolytic cleavage. For this reason, the study of the tissue proteome is becoming an increasingly important tool in biological and clinical research. In this chapter, we describe in detail the methodology for the analysis of tryptic digested peptides from aortic tissue extracts from mice with the aim to elucidate differences in the proteome between control and case or vascular diseased tissue samples. The method encompasses the analysis of these complex extracts in a single chromatographic run allowing for increased reproducibility. We also outline the main workflow for the processing of the generated data by statistical and bioinformatic analysis.en_UK
dc.relationAlbalat A, Mullen W, Husi H & Mischak H (2017) Tissue Proteomics in Vascular Disease. In: Touyz RM, Schiffrin EL (ed.). Hypertension: Tissue Proteomics in Vascular Disease. Methods in Molecular Biology, 1527, New York: Springer, pp. 53-60.-
dc.relation.ispartofseriesMethods in Molecular Biology, 1527-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectTissue proteomicsen_UK
dc.subjectFASP methoden_UK
dc.subjectMS/MS data analysisen_UK
dc.titleTissue Proteomics in Vascular Diseaseen_UK
dc.typePart of book or chapter of booken_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.type.statusBook Chapter: author post-print (pre-copy editing)-
dc.citation.btitleHypertension: Tissue Proteomics in Vascular Disease-
dc.publisher.addressNew York-
dc.contributor.affiliationComplex Systems-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
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