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dc.contributor.authorDa Boit, Mariasoleen_UK
dc.contributor.authorSibson, Rachaelen_UK
dc.contributor.authorSivasubramaniam, Selvarajen_UK
dc.contributor.authorMeakin, Judith Ren_UK
dc.contributor.authorGreig, Carolyn Aen_UK
dc.contributor.authorAspden, Richard Men_UK
dc.contributor.authorThies, Franken_UK
dc.contributor.authorJeromson, Stewarten_UK
dc.contributor.authorHamilton, David Leeen_UK
dc.contributor.authorSpeakman, John Ren_UK
dc.contributor.authorHambly, Catherineen_UK
dc.contributor.authorMangoni, Arduino Aen_UK
dc.contributor.authorPreston, Thomasen_UK
dc.contributor.authorGray, Stuart Ren_UK
dc.description.abstractBackground: Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n–3 polyunsaturated fatty acids (PUFAs) may enhance adaptations to resistance exercise in older women. To our knowledge, this possibility has not been investigated in men.  Objective: We sought to determine the effects of long-chain n–3 PUFA supplementation on resistance exercise training–induced increases in muscle mass and function and whether these effects differ between older men and women.  Design: Fifty men and women [men:n= 27, mean ± SD age: 70.6 ± 4.5 y, mean ± SD body mass index (BMI; in kg/m2): 25.6 ± 4.2; women:n= 23, mean ± SD age: 70.7 ± 3.3 y, mean ± SD BMI: 25.3 ± 4.7] were randomly assigned to either long-chain n–3 PUFA (n= 23; 3 g fish oil/d) or placebo (n= 27; 3 g safflower oil/d) and participated in lower-limb resistance exercise training twice weekly for 18 wk. Muscle size, strength, and quality (strength per unit muscle area), functional abilities, and circulating metabolic and inflammatory markers were measured before and after the intervention.  Results: Maximal isometric torque increased after exercise training to a greater (P <0.05) extent in the long-chain n–3 PUFA group than in the placebo group in women, with no differences (P >0.05) between groups in men. In both sexes, the effect of exercise training on maximal isokinetic torque at 30, 90, and 240° s−1, 4-m walk time, chair-rise time, muscle anatomic cross-sectional area, and muscle fat did not differ (P >0.05) between groups. There was a greater (P <0.05) increase in muscle quality in women after exercise training in the long-chain n–3 PUFA group than in the placebo group, with no such differences in men (P >0.05). Long-chain n–3 PUFAs resulted in a greater decrease (P <0.05) than the placebo in plasma triglyceride concentrations in both sexes, with no differences (P >0.05) in glucose, insulin, or inflammatory markers.  Conclusion: Long-chain n–3 PUFA supplementation augments increases in muscle function and quality in older women but not in older men after resistance exercise training. This trial was registered at as NCT02843009.en_UK
dc.publisherAmerican Society for Nutritionen_UK
dc.relationDa Boit M, Sibson R, Sivasubramaniam S, Meakin JR, Greig CA, Aspden RM, Thies F, Jeromson S, Hamilton DL, Speakman JR, Hambly C, Mangoni AA, Preston T & Gray SR (2017) Sex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trial. American Journal of Clinical Nutrition, 105 (1), pp. 151-158.
dc.rightsThis is an open access article distributed under the CC-BY license (
dc.subjectfatty acidsen_UK
dc.titleSex differences in the effect of fish-oil supplementation on the adaptive response to resistance exercise training in older people: A randomized controlled trialen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleAmerican Journal of Clinical Nutritionen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Exeteren_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationFlinders Universityen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorDa Boit, Mariasole|en_UK
local.rioxx.authorSibson, Rachael|en_UK
local.rioxx.authorSivasubramaniam, Selvaraj|en_UK
local.rioxx.authorMeakin, Judith R|en_UK
local.rioxx.authorGreig, Carolyn A|en_UK
local.rioxx.authorAspden, Richard M|en_UK
local.rioxx.authorThies, Frank|en_UK
local.rioxx.authorJeromson, Stewart|en_UK
local.rioxx.authorHamilton, David Lee|0000-0002-5620-4788en_UK
local.rioxx.authorSpeakman, John R|en_UK
local.rioxx.authorHambly, Catherine|en_UK
local.rioxx.authorMangoni, Arduino A|en_UK
local.rioxx.authorPreston, Thomas|en_UK
local.rioxx.authorGray, Stuart R|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameAm J Clin Nutr-2017-Da Boit-151-8.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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