Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/24115
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dc.contributor.authorMorris, Dylanen_UK
dc.contributor.authorCunningham, Margareten_UK
dc.contributor.authorAhimastos, Anna Aen_UK
dc.contributor.authorKingwell, Bronwen Aen_UK
dc.contributor.authorPappas, Eliseen_UK
dc.contributor.authorBourke, Michaelen_UK
dc.contributor.authorReid, Christopher Men_UK
dc.contributor.authorStijnen, Theoen_UK
dc.contributor.authorDalman, Ronald Len_UK
dc.contributor.authorAalami, Oliver Oen_UK
dc.contributor.authorLindeman, Jan Hen_UK
dc.contributor.authorNorman, Paul Een_UK
dc.contributor.authorWalker, Philip Jen_UK
dc.contributor.authorFitridge, Roberten_UK
dc.contributor.authorBourke, Bernieen_UK
dc.contributor.authorDear, Anthony Een_UK
dc.contributor.authorPinchbeck, Jennaen_UK
dc.contributor.authorJaeggi, Reneen_UK
dc.contributor.authorGolledge, Jonathanen_UK
dc.date.accessioned2016-10-03T21:05:56Z-
dc.date.available2016-10-03T21:05:56Z-
dc.date.issued2015-06-17en_UK
dc.identifier.other274en_UK
dc.identifier.urihttp://hdl.handle.net/1893/24115-
dc.description.abstractBackground  Experimental studies suggest that angiotensin II plays a central role in the pathogenesis of abdominal aortic aneurysm. This trial aims to evaluate the efficacy of the angiotensin receptor blocker telmisartan in limiting the progression of abdominal aortic aneurysm.  Methods/Design  Telmisartan in the management of abdominal aortic aneurysm (TEDY) is a multicentre, parallel-design, randomised, double-blind, placebo-controlled trial with an intention-to-treat analysis. We aim to randomly assign 300 participants with small abdominal aortic aneurysm to either 40 mg of telmisartan or identical placebo and follow patients over 2 years. The primary endpoint will be abdominal aortic aneurysm growth as measured by 1) maximum infra-renal aortic volume on computed tomographic angiography, 2) maximum orthogonal diameter on computed tomographic angiography, and 3) maximum diameter on ultrasound. Secondary endpoints include change in resting brachial blood pressure, abdominal aortic aneurysm biomarker profile and health-related quality of life. TEDY is an international collaboration conducted from major vascular centres in Australia, the United States and the Netherlands.  Discussion  Currently, no medication has been convincingly demonstrated to limit abdominal aortic aneurysm progression. TEDY will examine the potential of a promising treatment strategy for patients with small abdominal aortic aneurysms.  Trial registration  Australian and Leiden study centres: Australian New Zealand Clinical Trials RegistryACTRN12611000931976, registered on 30 August 2011; Stanford study centre: clinicaltrials.govNCT01683084, registered on 5 September 2012.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.relationMorris D, Cunningham M, Ahimastos AA, Kingwell BA, Pappas E, Bourke M, Reid CM, Stijnen T, Dalman RL, Aalami OO, Lindeman JH, Norman PE, Walker PJ, Fitridge R, Bourke B, Dear AE, Pinchbeck J, Jaeggi R & Golledge J (2015) TElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trial. Trials, 16, Art. No.: 274. https://doi.org/10.1186/s13063-015-0793-zen_UK
dc.rights© Morris et al. 2016 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectAbdominal aortic aneurysmen_UK
dc.subjectTrialen_UK
dc.subjectAngiotensinen_UK
dc.subjectTelmisartanen_UK
dc.titleTElmisartan in the management of abDominal aortic aneurYsm (TEDY): The study protocol for a randomized controlled trialen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/s13063-015-0793-zen_UK
dc.identifier.pmid26081587en_UK
dc.citation.jtitleTrialsen_UK
dc.citation.issn1745-6215en_UK
dc.citation.volume16en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailmc52@stir.ac.uken_UK
dc.citation.date17/06/2015en_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationBaker IDI Heart & Diabetes Instituteen_UK
dc.contributor.affiliationBaker IDI Heart & Diabetes Instituteen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationGosford Vascular Services Pty Ltden_UK
dc.contributor.affiliationMonash Universityen_UK
dc.contributor.affiliationLeiden Universityen_UK
dc.contributor.affiliationStanford Universityen_UK
dc.contributor.affiliationStanford Universityen_UK
dc.contributor.affiliationLeiden Universityen_UK
dc.contributor.affiliationUniversity of Western Australiaen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationUniversity of Adelaideen_UK
dc.contributor.affiliationGosford Vascular Services Pty Ltden_UK
dc.contributor.affiliationMonash Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.contributor.affiliationJames Cook Universityen_UK
dc.identifier.isiWOS:000356847800001en_UK
dc.identifier.scopusid2-s2.0-84933036846en_UK
dc.identifier.wtid551832en_UK
dc.contributor.orcid0000-0002-5850-9825en_UK
dc.date.accepted2015-06-02en_UK
dc.date.filedepositdate2016-08-24en_UK
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