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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein
Author(s): Macnaughton, Lindsay S
Wardle, Sophie
Witard, Oliver
McGlory, Chris
Hamilton, David Lee
Jeromson, Stewart
Lawrence, Claire
Wallis, Gareth A
Tipton, Kevin
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Issue Date: 10-Aug-2016
Date Deposited: 17-Aug-2016
Citation: Macnaughton LS, Wardle S, Witard O, McGlory C, Hamilton DL, Jeromson S, Lawrence C, Wallis GA & Tipton K (2016) The response of muscle protein synthesis following whole-body resistance exercise is greater following 40 g than 20 g of ingested whey protein. Physiological Reports, 4, Art. No.: e12893.
Abstract: The currently accepted amount of protein required to achieve maximal stimulation of myofibrillar protein synthesis (MPS) following resistance exercise is 20–25g. However, the influence of lean body mass (LBM) on the response of MPS to protein ingestion is unclear. Our aim was to assess the influence of LBM, both total and the amount activated during exercise, on the maximal response of MPS to ingestion of 20 or 40g of whey protein following a bout of whole‐body resistance exercise. Resistance‐trained males were assigned to a group with lower LBM (≤65kg; LLBMn=15) or higher LBM (≥70kg; HLBMn=15) and participated in two trials in random order. MPS was measured with the infusion of13C6‐phenylalanine tracer and collection of muscle biopsies following ingestion of either 20 or 40g protein during recovery from a single bout of whole‐body resistance exercise. A similar response of MPS during exercise recovery was observed between LBM groups following protein ingestion (20g – LLBM: 0.048±0.018%·h−1; HLBM: 0.051±0.014%·h−1; 40g – LLBM: 0.059±0.021%·h−1; HLBM: 0.059±0.012%·h−1). Overall (groups combined), MPS was stimulated to a greater extent following ingestion of 40g (0.059±0.020%·h−1) compared with 20g (0.049±0.020%·h−1;P=0.005) of protein. Our data indicate that ingestion of 40g whey protein following whole‐body resistance exercise stimulates a greater MPS response than 20g in young resistance‐trained men. However, with the current doses, the total amount of LBM does not seem to influence the response.
DOI Link: 10.14814/phy2.12893
Rights: © 2016 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
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