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dc.contributor.authorBasu, Ujani-
dc.contributor.authorGoodbrand, James A-
dc.contributor.authorMcMurdo, Marion E T-
dc.contributor.authorDonnan, Peter T-
dc.contributor.authorMcGilchrist, Mark M-
dc.contributor.authorFrost, Helen-
dc.contributor.authorGeorge, Jacob-
dc.contributor.authorWitham, Miles D-
dc.description.abstractBackground  Allopurinol reduces oxidative stress and interacts with purinergic signalling systems important in bone metabolism and muscle function. We assessed whether allopurinol use was associated with a reduced incidence of hip fracture in older people.  Methods  Analysis of prospective, routinely-collected health and social care data on patients undergoing health and social work assessment in a single geographical area over a 12year period. Exposure to allopurinol was derived from linked community prescribing data, and hospitalisation for hip fracture and comorbid disease was derived from linked hospitalisation data. Fine and Gray modelling was used to model time to hip fracture accounting for the competing risk of death, incorporating previous use of allopurinol, cumulative exposure to allopurinol as a time dependent variable, and covariate adjustments.  Results  17,308 patients were alive at the time of first social work assessment without previous hip fracture; the mean age was 73years. 10,171 (59%) were female, and 1155 (8%) had at least one exposure to allopurinol. 618 (3.6%) sustained a hip fracture, and 4226 (24%) died during a mean follow-up of 7.2years. In fully-adjusted analyses, each year of allopurinol exposure conferred a hazard ratio of 1.01 (95% CI 0.99, 1.02; p=0.37) for hip fracture and 1.00 (0.99, 1.01; p=0.47) for death. Previous use of allopurinol conferred a hazard ratio of 0.76 (0.45, 1.26; p=0.28) for hip fracture and 1.13 (0.99, 1.29; p=0.07) for death.  Conclusion  Greater cumulative use of allopurinol was not associated with a reduced risk of hip fracture or death in this cohort.en_UK
dc.relationBasu U, Goodbrand JA, McMurdo MET, Donnan PT, McGilchrist MM, Frost H, George J & Witham MD (2016) Association between allopurinol use and hip fracture in older patients, Bone, 84, pp. 189-193.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectRisk factoren_UK
dc.titleAssociation between allopurinol use and hip fracture in older patientsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationNinewells Hospital & Medical School-
dc.contributor.affiliationHS - Management and Support-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationUniversity of Dundee-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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