Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22945
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dc.contributor.authorGardner, Michaelen_UK
dc.contributor.authorBann, Danielen_UK
dc.contributor.authorWiley, Lauraen_UK
dc.contributor.authorCooper, Rachelen_UK
dc.contributor.authorHardy, Rebeccaen_UK
dc.contributor.authorNitsch, Dorotheaen_UK
dc.contributor.authorMartin-Ruiz, Carmenen_UK
dc.contributor.authorShiels, Paul Gen_UK
dc.contributor.authorSayer, Avan Aihieen_UK
dc.contributor.authorBarbieri, Michelangelaen_UK
dc.contributor.authorBekaert, Sofieen_UK
dc.contributor.authorBischoff, Clausen_UK
dc.contributor.authorBrooks-Wilson, Angelaen_UK
dc.contributor.authorChen, Weien_UK
dc.contributor.authorRobertson, Tonyen_UK
dc.date.accessioned2018-03-03T03:24:32Z-
dc.date.available2018-03-03T03:24:32Z-
dc.date.issued2014-03en_UK
dc.identifier.urihttp://hdl.handle.net/1893/22945-
dc.description.abstractBackground: It is widely believed that females have longer telomeres than males, although results from studies have been contradictory.  Methods: We carried out a systematic review and meta-analyses to test the hypothesis that in humans, females have longer telomeres than males and that this association becomes stronger with increasing age. Searches were conducted in EMBASE and MEDLINE (by November 2009) and additional datasets were obtained from study investigators. Eligible observational studies measured telomeres for both females and males of any age, had a minimum sample size of 100 and included participants not part of a diseased group. We calculated summary estimates using random-effects meta-analyses. Heterogeneity between studies was investigated using sub-group analysis and meta-regression.  Results: Meta-analyses from 36 cohorts (36,230 participants) showed that on average females had longer telomeres than males (standardised difference in telomere length between females and males 0.090, 95% CI 0.015, 0.166; age-adjusted). There was little evidence that these associations varied by age group (p = 1.00) or cell type (p = 0.29). However, the size of this difference did vary by measurement methods, with only Southern blot but neither real-time PCR nor Flow-FISH showing a significant difference. This difference was not associated with random measurement error.  Conclusions: Telomere length is longer in females than males, although this difference was not universally found in studies that did not use Southern blot methods. Further research on explanations for the methodological differences is required.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationGardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels PG, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W & Robertson T (2014) Gender and telomere length: Systematic review and meta-analysis. Experimental Gerontology, 51, pp. 15-27. https://doi.org/10.1016/j.exger.2013.12.004en_UK
dc.rightsAccepted refereed manuscript of: Gardner M, Bann D, Wiley L, Cooper R, Hardy R, Nitsch D, Martin-Ruiz C, Shiels PG, Sayer AA, Barbieri M, Bekaert S, Bischoff C, Brooks-Wilson A, Chen W & Robertson T (2014) Gender and telomere length: Systematic review and metaanalysis, Experimental Gerontology, 51, pp. 15-27. DOI: 10.1016/j.exger.2013.12.004 © 2014, Elsevier. Licensed under the Creative Commons Attribution- NonCommercial-NoDerivatives 4.0 International http://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en_UK
dc.subjectEpidemiologyen_UK
dc.subjectGenderen_UK
dc.subjectMeasurement methodsen_UK
dc.subjectSystematic review and meta-analysisen_UK
dc.subjectTelomere lengthen_UK
dc.titleGender and telomere length: Systematic review and meta-analysisen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.exger.2013.12.004en_UK
dc.identifier.pmid24365661en_UK
dc.citation.jtitleExperimental Gerontologyen_UK
dc.citation.issn0531-5565en_UK
dc.citation.volume51en_UK
dc.citation.spage15en_UK
dc.citation.epage27en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailtony.robertson@stir.ac.uken_UK
dc.citation.date21/12/2013en_UK
dc.description.notesAdditional co-authors: Cyrus Cooper, Kaare Christensen, Tim De Meyer, Ian Deary, Geoff Der, Ana Diez Roux, Annette Fitzpatrick, Anjum Hajat, Julius Halaschek-Wiener, Sarah Harris, Steven C. Hunt, Carol Jagger, Hyo-Sung Jeon, Robert Kaplan, Masayuki Kimura, Peter Lansdorp, Changyong Li, Toyoki Maeda, Massimo Mangino, Tim S. Nawrot, Peter Nilsson, Katarina Nordfjall, Giuseppe Paolisso, Fu Ren, Karl Riabowol, Goran Roos, Jan A. Staessen, Tim Spector, Nelson Tang, Brad Unryna, Pim van der Harst, Jean Woo, Chao Xing, Mohammad E. Yadegarfar, Jae Yong Parken_UK
dc.contributor.affiliationUniversity of Bristolen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationNewcastle Universityen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationUniversity College Londonen_UK
dc.contributor.affiliationLondon School of Hygiene and Tropical Medicineen_UK
dc.contributor.affiliationNewcastle Universityen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Southamptonen_UK
dc.contributor.affiliationSecond University of Naplesen_UK
dc.contributor.affiliationGhent Universityen_UK
dc.contributor.affiliationUniversity of Southern Denmarken_UK
dc.contributor.affiliationBC Cancer Agencyen_UK
dc.contributor.affiliationTulane Universityen_UK
dc.contributor.affiliationHS - Management and Support - LEGACYen_UK
dc.identifier.isiWOS:000331607800003en_UK
dc.identifier.scopusid2-s2.0-84892560321en_UK
dc.identifier.wtid580631en_UK
dc.contributor.orcid0000-0002-1962-5874en_UK
dc.date.accepted2013-12-13en_UK
dcterms.dateAccepted2013-12-13en_UK
dc.date.filedepositdate2016-03-10en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorGardner, Michael|en_UK
local.rioxx.authorBann, Daniel|en_UK
local.rioxx.authorWiley, Laura|en_UK
local.rioxx.authorCooper, Rachel|en_UK
local.rioxx.authorHardy, Rebecca|en_UK
local.rioxx.authorNitsch, Dorothea|en_UK
local.rioxx.authorMartin-Ruiz, Carmen|en_UK
local.rioxx.authorShiels, Paul G|en_UK
local.rioxx.authorSayer, Avan Aihie|en_UK
local.rioxx.authorBarbieri, Michelangela|en_UK
local.rioxx.authorBekaert, Sofie|en_UK
local.rioxx.authorBischoff, Claus|en_UK
local.rioxx.authorBrooks-Wilson, Angela|en_UK
local.rioxx.authorChen, Wei|en_UK
local.rioxx.authorRobertson, Tony|0000-0002-1962-5874en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2016-03-10en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/4.0/|2016-03-10|en_UK
local.rioxx.filenamegardner et al - Gender and telomere length.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0531-5565en_UK
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