Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22906
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dc.contributor.authorGabriel, Brendan Men_UK
dc.contributor.authorHamilton, David Leeen_UK
dc.contributor.authorTremblay, Annie Men_UK
dc.contributor.authorWackerhage, Henningen_UK
dc.date.accessioned2016-09-10T01:58:25Z-
dc.date.available2016-09-10T01:58:25Z-
dc.date.issued2016-05-15en_UK
dc.identifier.urihttp://hdl.handle.net/1893/22906-
dc.description.abstractThe ubiquitous transcriptional co-activators Yap (gene symbol Yap1) and Taz (gene symbol Wwtr1) regulate gene expression mainly by co-activating the Tead transcription factors. Yap and Taz lie at the centre of the Hippo signalling network and are not only regulated by the Hippo kinase cassette itself but also by a plethora of exercise-associated signals and signalling modules. These include mechanotransduction, the AKT-mTORC1 network, SMAD transcription factors, hypoxia, glucose, AMPK, adrenaline/epinephrine and angiotensin II through G protein-coupled receptors, and interleukin 6 (Il-6). Consequently exercise should alter Hippo signalling in several organs to mediate at least some aspects of organ-specific adaptations to exercise. Consistent with this idea Tead1 over expression in muscle fibres has been shown to promote a fast-to-slow fibre type switch whereas Yap in muscle fibres and cardiomyocytes promotes skeletal muscle and cardiac hypertrophy, respectively. Finally TEAD1, YAP1, VGLL2, VGLL3 and VGLL4 have all been linked in genome wide-association studies to body height, a key factor in sports.en_UK
dc.language.isoenen_UK
dc.publisherAmerican Physiological Societyen_UK
dc.relationGabriel BM, Hamilton DL, Tremblay AM & Wackerhage H (2016) The Hippo signal transduction network for exercise physiologists. Journal of Applied Physiology, 120 (10), pp. 1105-1117. https://doi.org/10.1152/japplphysiol.01076.2015en_UK
dc.rights[Gabriel-etal-japplphysiol-2016.pdf] The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights[Gabriel et al_japplphysiol_2015.full.pdf] This item has been embargoed for a period. During the embargo please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. Publisher policy allows this work to be made available in this repository. Published in Journal of Applied Physiology by American Physiological Society. The original publication is available at: http://dx.doi.org/10.1152/japplphysiol.01076.2015en_UK
dc.subjectExerciseen_UK
dc.subjectHippoen_UK
dc.subjectHypertrophyen_UK
dc.subjectSkeletal Muscleen_UK
dc.subjectYapen_UK
dc.titleThe Hippo signal transduction network for exercise physiologistsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2017-05-04en_UK
dc.rights.embargoreason[Gabriel-etal-japplphysiol-2016.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.rights.embargoreason[Gabriel et al_japplphysiol_2015.full.pdf] Publisher requires embargo of 12 months after formal publication.en_UK
dc.identifier.doi10.1152/japplphysiol.01076.2015en_UK
dc.identifier.pmid26940657en_UK
dc.citation.jtitleJournal of Applied Physiologyen_UK
dc.citation.issn1522-1601en_UK
dc.citation.issn8750-7587en_UK
dc.citation.volume120en_UK
dc.citation.issue10en_UK
dc.citation.spage1105en_UK
dc.citation.epage1117en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emaild.l.hamilton@stir.ac.uken_UK
dc.citation.date03/03/2016en_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationHarvard Universityen_UK
dc.contributor.affiliationUniversity of Aberdeenen_UK
dc.identifier.isiWOS:000376691800001en_UK
dc.identifier.scopusid2-s2.0-84983683612en_UK
dc.identifier.wtid576845en_UK
dc.contributor.orcid0000-0002-5620-4788en_UK
dc.date.accepted2016-03-02en_UK
dcterms.dateAccepted2016-03-02en_UK
dc.date.filedepositdate2016-03-04en_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorGabriel, Brendan M|en_UK
local.rioxx.authorHamilton, David Lee|0000-0002-5620-4788en_UK
local.rioxx.authorTremblay, Annie M|en_UK
local.rioxx.authorWackerhage, Henning|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2017-05-04en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||2017-05-03en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2017-05-04|en_UK
local.rioxx.filenameGabriel et al_japplphysiol_2015.full.pdfen_UK
local.rioxx.filecount2en_UK
local.rioxx.source8750-7587en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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