Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effect of Intensive Training on Mood With No Effect on Brain-Derived Neurotrophic Factor
Author(s): Piacentini, Maria Francesca
Witard, Oliver
Tonoli, Cajsa
Jackman, Sarah R
Turner, James E
Kies, Arie K
Jeukendrup, Asker E
Tipton, Kevin
Meeusen, Romain
Contact Email:
Keywords: Functional overreaching
psychological mood state
trained cyclists
Issue Date: Sep-2016
Date Deposited: 13-Jan-2016
Citation: Piacentini MF, Witard O, Tonoli C, Jackman SR, Turner JE, Kies AK, Jeukendrup AE, Tipton K & Meeusen R (2016) Effect of Intensive Training on Mood With No Effect on Brain-Derived Neurotrophic Factor. International Journal of Sports Physiology and Performance, 11 (6), pp. 824-830.
Abstract: Purpose Monitoring mood state is a useful tool for avoiding non-functional overreaching (NFOR). Brain derived neurotrophic factor (BDNF) is implicated in stress-related mood disorders. The purpose of the present study was to investigate the impact of intensified training-induced mood disturbance on plasma BDNF concentrations at rest and in response to exercise.  Methods Eight cyclists performed 1 week of normal (NT), 1 week of intensified (INT) and 1 week of recovery (REC) training. Fasted blood samples were collected before and after exercise, on day 7 of each training week and were analyzed for plasma BDNF and cortisol concentrations. A 24-item Profile Of Mood State questionnaire was administered on day 7 of each training week and global mood score (GMS) was calculated. Results Time trial performance was impaired during INT (p=0.01) and REC (p=0.02) compared with NT. Basal plasma cortisol (NT=153±16 ng/ml, INT=130±11 ng/ml, REC=150±14 ng/ml) and BDNF (NT=484±122 pg/ml, INT=488±122 pg/ml, REC=383±56 pg/ml) concentrations were similar between training conditions. Likewise, similar exercise-induced increases in cortisol and BDNF concentrations were observed between training conditions. GMS was 32% greater during INTvs.NT (P<0.001). Conclusion Consistent with a state of functional overreaching (FOR), impairments in performance and mood state with INT were restored after one week of REC. These results support evidence that mood changes before plasma BDNF concentrations as a biochemical marker of FOR and that cortisol is not a useful marker for predicting FOR.
DOI Link: 10.1123/ijspp.2015-0279
Rights: As accepted for publication in International Journal of Sports Physiology and Performance, ¬©Human Kinetics DOI:

Files in This Item:
File Description SizeFormat 
Piacentini_ijspp.2015-IT BDNF and mood (1).pdfFulltext - Accepted Version1.67 MBAdobe PDFView/Open

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.