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dc.contributor.authorRobertson, Tonyen_UK
dc.contributor.authorBatty, G Daviden_UK
dc.contributor.authorDer, Geoffen_UK
dc.contributor.authorGreen, Michael Jen_UK
dc.contributor.authorMcGlynn, Liane Men_UK
dc.contributor.authorMcIntyre, Alanen_UK
dc.contributor.authorShiels, Paul Gen_UK
dc.contributor.authorBenzeval, Michaelaen_UK
dc.description.abstractLower socioeconomic status (SES) is strongly associated with an increased risk of morbidity and premature mortality, but it is not known if the same is true for telomere length, a marker often used to assess biological ageing. The West of Scotland Twenty-07 Study was used to investigate this and consists of three cohorts aged approximately 35 (N = 775), 55 (N = 866) and 75 years (N = 544) at the time of telomere length measurement. Four sets of measurements of SES were investigated: those collected contemporaneously with telomere length assessment, educational markers, SES in childhood and SES over the preceding twenty years. We found mixed evidence for an association between SES and telomere length. In 35-year-olds, many of the education and childhood SES measures were associated with telomere length, i.e. those in poorer circumstances had shorter telomeres, as was intergenerational social mobility, but not accumulated disadvantage. A crude estimate showed that, at the same chronological age, social renters, for example, were nine years (biologically) older than home owners. No consistent associations were apparent in those aged 55 or 75. There is evidence of an association between SES and telomere length, but only in younger adults and most strongly using education and childhood SES measures. These results may reflect that childhood is a sensitive period for telomere attrition. The cohort differences are possibly the result of survival bias suppressing the SES-telomere association; cohort effects with regard different experiences of SES; or telomere possibly being a less effective marker of biological ageing at older ages.en_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationRobertson T, Batty GD, Der G, Green MJ, McGlynn LM, McIntyre A, Shiels PG & Benzeval M (2012) Is telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Study. PLoS ONE, 7 (7), Art. No.: e41805.
dc.rights© 2012 Robertson et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.subjectCohort Studiesen_UK
dc.subjectEducational Statusen_UK
dc.subjectMiddle Ageden_UK
dc.subjectSocial Classen_UK
dc.subjectTelomere Shorteningen_UK
dc.subjectTelomere: geneticsen_UK
dc.subjectTime Factorsen_UK
dc.subjectYoung Adulten_UK
dc.titleIs telomere length socially patterned? Evidence from the West of Scotland Twenty-07 Studyen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitlePLoS ONEen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationHS - Management and Support - LEGACYen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorRobertson, Tony|0000-0002-1962-5874en_UK
local.rioxx.authorBatty, G David|en_UK
local.rioxx.authorDer, Geoff|en_UK
local.rioxx.authorGreen, Michael J|en_UK
local.rioxx.authorMcGlynn, Liane M|en_UK
local.rioxx.authorMcIntyre, Alan|en_UK
local.rioxx.authorShiels, Paul G|en_UK
local.rioxx.authorBenzeval, Michaela|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenamerobertson (2012) plos one - telomere x ses.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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