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dc.contributor.authorDer, Geoffen_UK
dc.contributor.authorBatty, G Daviden_UK
dc.contributor.authorBenzeval, Michaelaen_UK
dc.contributor.authorDeary, Ianen_UK
dc.contributor.authorGreen, Michael Jen_UK
dc.contributor.authorMcGlynn, Liane Men_UK
dc.contributor.authorMcIntyre, Alanen_UK
dc.contributor.authorRobertson, Tonyen_UK
dc.contributor.authorShiels, Paul Gen_UK
dc.description.abstractBACKGROUND: The search for biomarkers of aging (BoAs) has been largely unsuccessful to-date and there is widespread skepticism about the prospects of finding any that satisfy the criteria developed by the American Federation of Aging Research. This may be because the criteria are too strict or because a composite measure might be more appropriate. Telomere length has attracted a great deal of attention as a candidate BoA. We investigate whether it meets the criteria to be considered as a single biomarker of aging, and whether it makes a useful contribution to a composite measure. METHODOLOGY/PRINCIPAL FINDINGS: Using data from a large population based study, we show that telomere length is associated with age, with several measures of physical and cognitive functioning that are related to normal aging, and with three measures of overall health. In the majority of cases, telomere length adds predictive power to that of age, although it was not nearly as good a predictor overall. We used principal components analysis to form two composites from the measures of functioning, one including telomere length and the other not including it. These composite BoAs were better predictors of the health outcomes than chronological age. There was little difference between the two composites. CONCLUSIONS: Telomere length does not satisfy the strict criteria for a BoA, but does add predictive power to that of chronological age. Equivocal results from previous studies might be due to lack of power or the choice of measures examined together with a focus on single biomarkers. Composite biomarkers of aging have the potential to outperform age and should be considered for future research in this area.en_UK
dc.publisherPublic Library of Scienceen_UK
dc.relationDer G, Batty GD, Benzeval M, Deary I, Green MJ, McGlynn LM, McIntyre A, Robertson T & Shiels PG (2012) Is telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?. PLoS ONE, 7 (9), Art. No.: e45166.
dc.rights© Der et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_UK
dc.subjectAging: geneticsen_UK
dc.subjectBiological Markersen_UK
dc.subjectCognition: physiologyen_UK
dc.subjectCross-Sectional Studiesen_UK
dc.subjectLongitudinal Studiesen_UK
dc.subjectMiddle Ageden_UK
dc.subjectPredictive Value of Testsen_UK
dc.subjectPrincipal Component Analysisen_UK
dc.subjectTelomere Homeostasisen_UK
dc.subjectTelomere Homeostasis: geneticsen_UK
dc.subjectTelomere: chemistryen_UK
dc.subjectTelomere: geneticsen_UK
dc.titleIs telomere length a biomarker for aging: cross-sectional evidence from the west of Scotland?en_UK
dc.typeJournal Articleen_UK
dc.citation.jtitlePLoS ONEen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationHS - Management and Support - LEGACYen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorDer, Geoff|en_UK
local.rioxx.authorBatty, G David|en_UK
local.rioxx.authorBenzeval, Michaela|en_UK
local.rioxx.authorDeary, Ian|en_UK
local.rioxx.authorGreen, Michael J|en_UK
local.rioxx.authorMcGlynn, Liane M|en_UK
local.rioxx.authorMcIntyre, Alan|en_UK
local.rioxx.authorRobertson, Tony|0000-0002-1962-5874en_UK
local.rioxx.authorShiels, Paul G|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenamerobertson (2012) plos one - telomere x ses.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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