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dc.contributor.authorMacaluso, Filippo-
dc.contributor.authorBrooks, Naomi-
dc.contributor.authorNiesler, Carola U-
dc.contributor.authorMyburgh, Kathryn H-
dc.description.abstractINTRODUCTION We investigated changes in satellite cell (SC) pool size after an acute bout of strenuous exercise and evaluated the influence of baseline SC count and fiber type. METHODS Participants completed a downhill running (DHR) intervention (5 × 8 min, 2-min rest; 80% VO2max ; -10% gradient). Muscle biopsies were taken 7 days before VO₂max and 7-9 days after the DHR intervention. Delayed-onset muscle soreness (DOMS) and creatine kinase activity (CK) were measured on days 1, 2, 7, and 9 post-DHR. SCs were identified by Pax7 and laminin staining. Relative distribution of MHC isoforms was determined by electrophoresis. RESULTS DOMS and CK peaked on day 1 post-DHR (P < 0.01). The SC pool increased (26%) after DHR (P = 0.005). SCs/total myonuclei after recovery correlated with baseline SCs (r = 0.979, P = 0.003) and VO₂max (r = 0.956, P = 0.011), whereas change in SC pool (Pax7(+) cells/total myonuclei: recovery minus baseline) tended to correlate with percent MHC II (r = 0.848; P = 0.06). CONCLUSION Interindividual physiological characteristics affect SC pool expansion after a single bout of DHR and are influenced by VO₂max .en_UK
dc.relationMacaluso F, Brooks N, Niesler CU & Myburgh KH (2013) Satellite cell pool expansion is affected by skeletal muscle characteristics, Muscle and Nerve, 48 (1), pp. 109-116.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectdownhill runningen_UK
dc.subjectfiber typingen_UK
dc.titleSatellite cell pool expansion is affected by skeletal muscle characteristicsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleMuscle and Nerve-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationUniversity of Stellenbosch, South Africa-
dc.contributor.affiliationUniversity of KwaZulu-Natal-
dc.contributor.affiliationUniversity of Stellenbosch, South Africa-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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