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dc.contributor.authorBrooks, Naomien_UK
dc.contributor.authorCadena, Samuel Men_UK
dc.contributor.authorVannier, Edouarden_UK
dc.contributor.authorCloutier, Gregoryen_UK
dc.contributor.authorCarambula, Silviaen_UK
dc.contributor.authorMyburgh, Kathryn Hen_UK
dc.contributor.authorRoubenoff, Ronennen_UK
dc.contributor.authorCastaneda-Sceppa, Carmenen_UK
dc.description.abstractSpaceflight and bed rest (BR) lead to muscle atrophy. This study assessed the effect of essential amino acid (EAA) supplementation and resistance training with decreased energy intake on molecular changes in skeletal muscle after 28-day BR and 14-day recovery. Thirty-one men (31-55 years) subjected to an 8 ± 6% energy deficit were randomized to receive EAA without resistance training (AA, n = 7), or EAA 3 h after (RT, n = 12) or 5 min before (AART, n = 12) resistance training. During BR, myostatin transcript levels increased twofold in the AA group. During recovery, insulin-like growth factor-1 (IGF-1) mRNA increased in all groups, whereas Pax7, MyoD, myogenin, and MRF4 transcripts increased in AA only (all P < 0.05). MAFbx transcripts decreased twofold with AA and RT. Satellite cells did not change during BR or recovery. This suggests that EAA alone is the least protective countermeasure to muscle loss, and several molecular mechanisms are proposed by which exercise attenuates muscle atrophy during BR with energy deficit.en_UK
dc.relationBrooks N, Cadena SM, Vannier E, Cloutier G, Carambula S, Myburgh KH, Roubenoff R & Castaneda-Sceppa C (2010) Effects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recovery. Muscle and Nerve, 42 (6), pp. 927-935.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectbed resten_UK
dc.subjectenergy deficiten_UK
dc.subjectessential amino acid supplementationen_UK
dc.subjectmyogenic factorsen_UK
dc.subjectresistance exerciseen_UK
dc.titleEffects of resistance exercise combined with essential amino acid supplementation and energy deficit on markers of skeletal muscle atrophy and regeneration during bed rest and active recoveryen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Brooks et al. Muscle Nerve 2010.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleMuscle and Nerveen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationTufts Medical Center, Boston, USAen_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationUniversity of Stellenbosch, South Africaen_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationNortheastern University (US)en_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBrooks, Naomi|0000-0002-0269-3475en_UK
local.rioxx.authorCadena, Samuel M|en_UK
local.rioxx.authorVannier, Edouard|en_UK
local.rioxx.authorCloutier, Gregory|en_UK
local.rioxx.authorCarambula, Silvia|en_UK
local.rioxx.authorMyburgh, Kathryn H|en_UK
local.rioxx.authorRoubenoff, Ronenn|en_UK
local.rioxx.authorCastaneda-Sceppa, Carmen|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameBrooks et al. Muscle Nerve 2010.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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