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dc.contributor.authorBrooks, Naomien_UK
dc.contributor.authorCadena, Samuel Men_UK
dc.contributor.authorCloutier, Gregory Jen_UK
dc.contributor.authorVega-Lopez, Soniaen_UK
dc.contributor.authorRoubenoff, Ronennen_UK
dc.contributor.authorCastaneda-Sceppa, Carmenen_UK
dc.description.abstractObjective: Muscle loss and metabolic changes occur with disuse [i.e. bed rest (BR)]. We hypothesized that BR would lead to a metabolically unhealthy profile defined by: increased circulating tumor necrosis factor (TNF)-α, decreased circulating insulin-like-growth-factor (IGF)-1, decreased HDL-cholesterol, and decreased muscle density (MD; measured by mid-thigh computerized tomography).  Methods: We investigated the metabolic profile after 28 days of BR with 8±6% energy deficit in male individuals (30-55 years) randomized to resistance exercise with amino acid supplementation (RT, n=24) or amino acid supplementation alone (EAA, n=7). Upper and lower body exercises were performed in the horizontal position. Blood samples were taken at baseline, after 28 days of BR and 14 days of recovery.  Results: We found a shift toward a metabolically unfavourable profile after BR [compared to baseline (BLN)] in both groups as shown by decreased HDL-cholesterol levels (EAA: BLN: 39±4 vs. BR: 32±2 mg/dL, RT: BLN: 39±1 vs. BR: 32±1 mg/dL; p<0.001) and Low MD (EAA: BLN: 27±4 vs. BR: 22±3 cm2, RT: BLN: 28±2 vs. BR: 23±2 cm2; p<0.001). A healthier metabolic profile was maintained with exercise, including NormalMD (EAA: BLN: 124±6 vs. BR: 110±5 cm2, RT: BLN: 132±3 vs. BR: 131±4 cm2; p<0.001, time-by-group); although, exercise did not completely alleviate the unfavourable metabolic changes seen with BR. Interestingly, both groups had increased plasma IGF-1 levels (EAA: BLN:168±22 vs. BR 213±20 ng/mL, RT: BLN:180±10 vs. BR: 219±13 ng/mL; p<0.001) and neither group showed TNFα changes (p>0.05).  Conclusions: We conclude that RT can be incorporated to potentially offset the metabolic complications of BR.en_UK
dc.publisherIvyspring International Publisheren_UK
dc.relationBrooks N, Cadena SM, Cloutier GJ, Vega-Lopez S, Roubenoff R & Castaneda-Sceppa C (2014) Influence of exercise on the metabolic profile caused by 28 days of bed rest with energy deficit and amino acid supplementation in healthy men. International Journal of Medical Sciences, 11 (12), pp. 1248-1257.
dc.rightsThis article is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be given.en_UK
dc.subjectresistance trainingen_UK
dc.subjectessential amino acidsen_UK
dc.subjectenergy deficiten_UK
dc.subjectmetabolic profileen_UK
dc.titleInfluence of exercise on the metabolic profile caused by 28 days of bed rest with energy deficit and amino acid supplementation in healthy menen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleInternational Journal of Medical Sciencesen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationNortheastern University (US)en_UK
dc.contributor.affiliationArizona State Universityen_UK
dc.contributor.affiliationTufts Universityen_UK
dc.contributor.affiliationTufts Universityen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBrooks, Naomi|0000-0002-0269-3475en_UK
local.rioxx.authorCadena, Samuel M|en_UK
local.rioxx.authorCloutier, Gregory J|en_UK
local.rioxx.authorVega-Lopez, Sonia|en_UK
local.rioxx.authorRoubenoff, Ronenn|en_UK
local.rioxx.authorCastaneda-Sceppa, Carmen|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameBrooks et al. Int J Med Sci 2014.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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