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dc.contributor.authorBooth, Joanneen_UK
dc.contributor.authorConnelly, Lesleyen_UK
dc.contributor.authorLawrence, Maggieen_UK
dc.contributor.authorChalmers, Campbellen_UK
dc.contributor.authorJoice, Saraen_UK
dc.contributor.authorBecker, Clarissaen_UK
dc.contributor.authorDougall, Nadineen_UK
dc.description.abstractBackground  Several studies suggest that perceived psychosocial stress is associated with increased risk of stroke; however results are inconsistent with regard to definitions and measurement of perceived stress, features of individual study design, study conduct and conclusions drawn and no meta-analysis has yet been published. We performed a systematic review and meta-analysis of studies assessing association between perceived psychosocial stress and risk of stroke in adults.The results of the meta-analysis are presented.  Methods  Systematic searches of MEDLINE, EMBASE, CINAHL, PsycInfo, and Cochrane Database of Systematic Reviews were undertaken between 1980 and June 2014. Data extraction and quality appraisal was performed by two independent reviewers. Hazard ratios (HR) and odds ratios (OR) were pooled where appropriate.  Results 14 studies were included in the meta-analysis, 10 prospective cohort, 4 case–control design. Overall pooled adjusted effect estimate for risk of total stroke in subjects exposed to general or work stress or to stressful life events was 1.33 (95% confidence interval [CI], 1.17, 1.50;P < 0.00001). Sub-group analyses showed perceived psychosocial stress to be associated with increased risk of fatal stroke (HR 1.45 95% CI, 1.19,1.78;P = 0.0002), total ischaemic stroke (HR 1.40 95% CI, 1.00,1.97;P = 0.05) and total haemorrhagic stroke (HR 1.73 95% CI, 1.33,2.25;P > 0.0001).A sex difference was noted with higher stroke risk identified for women (HR 1.90 95% CI, 1.4, 2.56:P < 0.0001) compared to men (HR 1.24 95% CI, 1.12, 1.36;P < 0.0001).  Conclusions  Current evidence indicates that perceived psychosocial stress is independently associated with increased risk of stroke.en_UK
dc.publisherBioMed Centralen_UK
dc.relationBooth J, Connelly L, Lawrence M, Chalmers C, Joice S, Becker C & Dougall N (2015) Evidence of perceived psychosocial stress as a risk factor for stroke in adults: A meta-analysis. BMC Neurology, 15 (1), Art. No.: 233.
dc.rights© 2015 Booth et al. Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.en_UK
dc.subjectStress, Psychologicalen_UK
dc.subjectRisk factoren_UK
dc.titleEvidence of perceived psychosocial stress as a risk factor for stroke in adults: A meta-analysisen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleBMC Neurologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
dc.contributor.affiliationNHS Lanarkshireen_UK
dc.contributor.affiliationMassey Universityen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBooth, Joanne|en_UK
local.rioxx.authorConnelly, Lesley|en_UK
local.rioxx.authorLawrence, Maggie|en_UK
local.rioxx.authorChalmers, Campbell|en_UK
local.rioxx.authorJoice, Sara|en_UK
local.rioxx.authorBecker, Clarissa|en_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameBooth et al final published 2015.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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