Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/22580
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dc.contributor.authorBrown, Frankie F-
dc.contributor.authorBigley, Austin B-
dc.contributor.authorRoss, J C-
dc.contributor.authorLaVoy, Emily C-
dc.contributor.authorSimpson, Richard-
dc.contributor.authorGalloway, S D-
dc.date.accessioned2016-09-09T22:48:07Z-
dc.date.issued2015-12-01-
dc.identifier.urihttp://hdl.handle.net/1893/22580-
dc.description.abstractPurpose: To investigate the T-lymphocyte response to a period of increased training volume in trained females compared to habitual activity in female controls.  Methods: Thirteen trained female (19.8±1.9yrs) soccer players were monitored during a two-week long high volume training period (increased by 39%) and thirteen female untrained (20.5±2.2yrs) controls were monitored during two-weeks of habitual activity. Blood lymphocytes, collected at rest, were isolated before and after the two-week period. Isolated lymphocytes were assessed for the cell surface expression of the co-receptor CD28, a marker of T-lymphocyte naivety, and CD57 a marker used to identify highly-differentiated T-lymphocytes. Co-expression of these markers was identified on helper CD4+ and cytotoxic CD8+ T-lymphocytes. In addition a further population of γδ+ T-lymphocytes were identified. Plasma was used to determine Cytomegalovirus (CMV) serostatus.  Results: No difference was observed in the T-lymphocyte populations following the two-week period of increased volume training. At baseline the number of total CD3+, cytotoxic CD8+, naïve (CD8+ CD28+ CD57−), intermediate (CD8+ CD28+ CD57+) T-lymphocytes and the number and proportion of γδ+ T-lymphocytes were greater in the trained compared to the untrained females (p<0.05). The proportion of CD4+ T-lymphocytes was greater in the untrained compared to the trained (p<0.05), in turn the CD4+:CD8+ ratio was also greater in the untrained females (p<0.05). Inclusion of percentage body fat as a covariate removed the main effect of training status in all T-lymphocyte sub-populations, with the exception of the γδ+ T-lymphocyte population. 8% of the untrained group was defined as positive for CMV whereas 23% of the trained group was positive for CMV. However, CMV was not a significant covariate in the analysis of T-lymphocyte proportions.  Conclusion: The period of high volume training had no effect on T-lymphocyte populations in trained females. However, baseline training status differences were evident between groups. This indicates that long-term exercise training, as opposed to short-term changes in exercise volume, appears to elicit discernible changes in the composition of the blood T-lymphocyte pool.en_UK
dc.language.isoen-
dc.publisherElsevier-
dc.relationBrown FF, Bigley AB, Ross JC, LaVoy EC, Simpson R & Galloway SD (2015) T-lymphocyte populations following a period of high volume training in female soccer players, Physiology and Behavior, 152 (Part A), pp. 175-181.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectCD4+ T-lymphocytesen_UK
dc.subjectCD8+ T-lymphocytesen_UK
dc.subjectTraineden_UK
dc.subjectUntraineden_UK
dc.subjectDieten_UK
dc.subjectCMV infectionen_UK
dc.subjectγδ+ T-lymphocytesen_UK
dc.titleT-lymphocyte populations following a period of high volume training in female soccer playersen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1016/j.physbeh.2015.09.027-
dc.identifier.pmid26432452-
dc.citation.jtitlePhysiology and Behavior-
dc.citation.issn0031-9384-
dc.citation.volume152-
dc.citation.issuePart A-
dc.citation.spage175-
dc.citation.epage181-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emails.d.r.galloway@stir.ac.uk-
dc.citation.date30/09/2015-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationUniversity of Stirling-
dc.contributor.affiliationSport-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000366953600024-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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