Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Associations of sedentary time with fat distribution in a high-risk population
Author(s): Henson, Joseph
Edwardson, Charlotte L
Morgan, Bruno
Horsfield, Mark A
Bodicoat, Danielle H
Biddle, Stuart J H
Gorely, Trish
Nimmo, Myra A
Mccann, Gerry P
Khunti, Kamlesh
Davies, Melanie J
Yates, Thomas
Contact Email:
Keywords: Type 2 Diabetes
Sedentary Behavior
High Risk
Fat Distribution
Primary Care
Issue Date: Aug-2015
Date Deposited: 29-Oct-2015
Citation: Henson J, Edwardson CL, Morgan B, Horsfield MA, Bodicoat DH, Biddle SJH, Gorely T, Nimmo MA, Mccann GP, Khunti K, Davies MJ & Yates T (2015) Associations of sedentary time with fat distribution in a high-risk population. Medicine and Science in Sports and Exercise, 47 (8), pp. 1727-1734.
Abstract: Purpose: The effect of sedentary behavior on regional fat deposition, independent of physical activity, remains equivocal. We examined the cross-sectional associations between objectively measured sedentary time and markers of regional fat distribution (heart, liver, visceral, subcutaneous, and total body fat) in a population at a high risk of type 2 diabetes mellitus (T2DM).  Methods: Participants were recruited from primary care to two diabetes prevention programs. Sedentary time (<25 counts per 15 s) was measured using ActiGraph GT3X accelerometers. Heart, liver, visceral, subcutaneous, and total body fat were quantified using magnetic resonance images. Fat volumes were calculated by multiplying the cross-sectional areas of the fat-containing pixels by the slice thickness. The liver fat percentage was measured using a representative region of interest created in the right lobe of the liver, avoiding the main portal veins. Linear regression models examined the association of sedentary time with markers of regional fat deposition.  Results: Sixty-six participants (age, 47.9 ± 16.2 yr; male, 50.0%) were included. After adjustment for several covariates, including glycemia, whole-body fat, and moderate-to-vigorous physical activity, each 30 min of sedentary time was associated with 15.7 cm3higher heart fat (P= 0.008), 1.2% higher liver fat (P= 0.026), and 183.7 cm3higher visceral fat (P= 0.039).  Conclusions: This study provides new evidence suggesting that objectively measured sedentary behavior may have an independent association with heart, liver, and visceral fat in individuals at a high risk of T2DM.
DOI Link: 10.1249/MSS.0000000000000572
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Licence URL(s):

Files in This Item:
File Description SizeFormat 
Edwardson et al_MSSE_2015.pdfFulltext - Published Version841.06 kBAdobe PDFUnder Embargo until 3000-01-01    Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.