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dc.contributor.authorBrown, Richarden_UK
dc.contributor.authorLandau, Sabineen_UK
dc.contributor.authorHindle, Johnen_UK
dc.contributor.authorPlayfer, Jeremyen_UK
dc.contributor.authorMike, Samuelen_UK
dc.contributor.authorWilson, Kenen_UK
dc.contributor.authorHurt, Catherineen_UK
dc.contributor.authorAnderson, Rachelen_UK
dc.contributor.authorCarnell, Joannaen_UK
dc.contributor.authorDickinson, Lucyen_UK
dc.contributor.authorGibson, Granten_UK
dc.contributor.authorVan Schaick, Rachelen_UK
dc.contributor.authorSellwood, Katieen_UK
dc.contributor.authorThomas, Bonnitaen_UK
dc.contributor.authorBurn, Daviden_UK
dc.description.abstractBackground: Depression and anxiety are common in Parkinson's disease (PD) and although clinically important remain poorly understood and managed. To date, research has tended to treat depression and anxiety as distinct phenomena. There is growing evidence for heterogeneity in PD in the motor and cognitive domains, with implications for pathophysiology and outcome. Similar heterogeneity may exist in the domain of depression and anxiety. Objective: To identify the main anxiety and depression related subtype(s) in PD and their associated demographic and clinical features. Methods: A sample of 513 patients with PD received a detailed assessment of depression and anxiety related symptomatology. Latent Class Analysis (LCA) was used to identify putative depression and anxiety related subtypes. Results: LCA identified four classes, two interpretable as ‘anxiety related': one anxiety alone (22.0%) and the other anxiety coexisting with prominent depressive symptoms (8.6%). A third subtype (9%) showed a prominent depressive profile only without significant anxiety. The final class (60.4%) showed a low probability of prominent affective symptoms. The validity of the four classes was supported by distinct patterns of association with important demographic and clinical variables. Conclusion: Depression in PD may manifest in two clinical phenotypes, one ‘anxious-depressed' and the other ‘depressed'. However, a further large proportion of patients can have relatively isolated anxiety. Further study of these putative phenotypes may identify important differences in pathophysiology and other aetiologically important factors and focus research on developing more targeted and effective treatment.en_UK
dc.publisherBMJ Publishing Groupen_UK
dc.relationBrown R, Landau S, Hindle J, Playfer J, Mike S, Wilson K, Hurt C, Anderson R, Carnell J, Dickinson L, Gibson G, Van Schaick R, Sellwood K, Thomas B & Burn D (2011) Depression and Anxiety Related Subtypes in Parkinson's Disease. Journal of Neurology, Neurosurgery, and Psychiatry, 82 (7), pp. 803-809.
dc.rightsPublisher policy allows this work to be made available in this repository. Published in J Neurol Neurosurg Psychiatry 2011;82:803-809 doi:10.1136/jnnp.2010.213652 by BMJ Publishing Group The original publication is available at:
dc.titleDepression and Anxiety Related Subtypes in Parkinson's Diseaseen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleJournal of Neurology, Neurosurgery and Psychiatryen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.description.notes*for the PROMS-PD Study Groupen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationBangor Universityen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationCity University Londonen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationCity University Londonen_UK
dc.contributor.affiliationNewcastle Universityen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationDementia and Ageingen_UK
dc.contributor.affiliationUniversity of Liverpoolen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationNewcastle Universityen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBrown, Richard|en_UK
local.rioxx.authorLandau, Sabine|en_UK
local.rioxx.authorHindle, John|en_UK
local.rioxx.authorPlayfer, Jeremy|en_UK
local.rioxx.authorMike, Samuel|en_UK
local.rioxx.authorWilson, Ken|en_UK
local.rioxx.authorHurt, Catherine|en_UK
local.rioxx.authorAnderson, Rachel|en_UK
local.rioxx.authorCarnell, Joanna|en_UK
local.rioxx.authorDickinson, Lucy|en_UK
local.rioxx.authorGibson, Grant|0000-0001-8249-4697en_UK
local.rioxx.authorVan Schaick, Rachel|en_UK
local.rioxx.authorSellwood, Katie|en_UK
local.rioxx.authorThomas, Bonnita|en_UK
local.rioxx.authorBurn, David|en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenamedepression and anxiety subtypes in Parkinson's disease.pdfen_UK
Appears in Collections:Faculty of Social Sciences Journal Articles

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