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Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: The PRECIS-2 tool: Designing trials that are fit for purpose
Author(s): Loudon, Kirsty
Treweek, Shaun
Sullivan, Frank
Donnan, Peter T
Thorpe, Kevin E
Zwarenstein, Merrick
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Issue Date: May-2015
Citation: Loudon K, Treweek S, Sullivan F, Donnan PT, Thorpe KE & Zwarenstein M (2015) The PRECIS-2 tool: Designing trials that are fit for purpose, BMJ, 350, Art. No.: h2147.
Abstract: PRECIS is a tool to help trialists make design decisions consistent with the intended purpose of their trial. This paper gives guidance on how to use an improved, validated version, PRECIS-2, which has been developed with the help of over 80 international trialists, clinicians, and policymakers. Keeping the original simple wheel format, PRECIS-2 has nine domains-eligibility criteria, recruitment, setting, organisation, flexibility (delivery), flexibility (adherence), follow-up, primary outcome, and primary analysis-scored from 1 (very explanatory) to 5 (very pragmatic) to facilitate domain discussion and consensus. It is hoped PRECIS-2 will be valuable in supporting the explicit matching of design decisions to how the trial results are intended to be used
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Rights: This article is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be given. No commercial reuse

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