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dc.contributor.authorEccles, Suzanne Aen_UK
dc.contributor.authorAboagye, Eric Oen_UK
dc.contributor.authorAli, Simaken_UK
dc.contributor.authorAnderson, Annie Sen_UK
dc.contributor.authorArmes, Joen_UK
dc.contributor.authorBerditchevski, Fedoren_UK
dc.contributor.authorBlaydes, Jeremy Pen_UK
dc.contributor.authorBrennan, Keithen_UK
dc.contributor.authorBrown, Nicolaen_UK
dc.contributor.authorBryant, Helenen_UK
dc.contributor.authorBundred, Nigel Jen_UK
dc.contributor.authorBurchell, Joy Men_UK
dc.contributor.authorCampbell, Annaen_UK
dc.contributor.authorCarroll, Jason Sen_UK
dc.contributor.authorHubbard, Gillen_UK
dc.description.abstractIntroduction: Breast cancer remains a significant scientific, clinical and societal challenge. This gap analysis has reviewed and critically assessed enduring issues and new challenges emerging from recent research, and proposes strategies for translating solutions into practice. Methods: More than 100 internationally recognised specialist breast cancer scientists, clinicians and healthcare professionals collaborated to address nine thematic areas: genetics, epigenetics and epidemiology; molecular pathology and cell biology; hormonal influences and endocrine therapy; imaging, detection and screening; current/novel therapies and biomarkers; drug resistance; metastasis, angiogenesis, circulating tumour cells, cancer ‘stem' cells; risk and prevention; living with and managing breast cancer and its treatment. The groups developed summary papers through an iterative process which, following further appraisal from experts and patients, were melded into this summary account. Results: The 10 major gaps identified were: (1) understanding the functions and contextual interactions of genetic and epigenetic changes in normal breast development and during malignant transformation; (2) how to implement sustainable lifestyle changes (diet, exercise and weight) and chemopreventive strategies; (3) the need for tailored screening approaches including clinically actionable tests; (4) enhancing knowledge of molecular drivers behind breast cancer subtypes, progression and metastasis; (5) understanding the molecular mechanisms of tumour heterogeneity, dormancy, de novo or acquired resistance and how to target key nodes in these dynamic processes; (6) developing validated markers for chemosensitivity and radiosensitivity; (7) understanding the optimal duration, sequencing and rational combinations of treatment for improved personalised therapy; (8) validating multimodality imaging biomarkers for minimally invasive diagnosis and monitoring of responses in primary and metastatic disease; (9) developing interventions and support to improve the survivorship experience; (10) a continuing need for clinical material for translational research derived from normal breast, blood, primary, relapsed, metastatic and drug-resistant cancers with expert bioinformatics support to maximise its utility. The proposed infrastructural enablers include enhanced resources to support clinically relevant in vitro and in vivo tumour models; improved access to appropriate, fully annotated clinical samples; extended biomarker discovery, validation and standardisation; and facilitated cross-discipline working. Conclusions: With resources to conduct further high-quality targeted research focusing on the gaps identified, increased knowledge translating into improved clinical care should be achievable within five years.en_UK
dc.publisherBioMed Centralen_UK
dc.relationEccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K, Brown N, Bryant H, Bundred NJ, Burchell JM, Campbell A, Carroll JS & Hubbard G (2013) Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer. Breast Cancer Research, 15 (5), Art. No.: R92.
dc.rights© 2013 Eccles et al.; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_UK
dc.titleCritical research gaps and translational priorities for the successful prevention and treatment of breast canceren_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleBreast Cancer Researchen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.description.notesAdditional co-authors: Robert B Clarke, Charlotte E Coles, Gary JR Cook, Angela Cox, Nicola J Curtin, Lodewijk V Dekker, Isabel dos Santos Silva, Stephen W Duffy, Douglas F Easton, Diana M Eccles, Dylan R Edwards, Joanne Edwards, D Gareth Evans, Deborah F Fenlon, James M Flanagan, Claire Foster, William M Gallagher, Montserrat Garcia-Closas, Julia M W Gee, Andy J Gescher, Vicky Goh, Ashley M Groves, Amanda J Harvey, Michelle Harvie, Bryan T Hennessy, Stephen Hiscox, Ingunn Holen, Sacha J Howell, Anthony Howell, Nick Hulbert-Williams, Myra S Hunter, Bharat Jasani, Louise J Jones, Timothy J Key, Cliona C Kirwan, Anthony Kong, Ian H Kunkler, Simon P Langdon, Martin O Leach, David J Mann, John F Marshall, Lesley Ann Martin, Stewart G Martin, Jennifer E Macdougall, David W Miles, William R Miller, Joanna R Morris, Sue M Moss, Paul Mullan, Rachel Natrajan, James PB O’Connor, Rosemary O’Connor, Carlo Palmieri, Paul D P Pharoah, Emad A Rakha, Elizabeth Reed, Simon P Robinson, Erik Sahai, John M Saxton, Peter Schmid, Matthew J Smalley, Valerie Speirs, Robert Stein, John Stingl, Charles H Streuli, Andrew N J Tutt, Galina Velikova, Rosemary A Walker, Christine J Watson, Kaye J Williams, Leonie S Young and Alastair M Thompsonen_UK
dc.contributor.affiliationInstitute of Cancer Researchen_UK
dc.contributor.affiliationImperial College Londonen_UK
dc.contributor.affiliationImperial College Londonen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationUniversity of Birminghamen_UK
dc.contributor.affiliationUniversity of Southamptonen_UK
dc.contributor.affiliationUniversity of Manchesteren_UK
dc.contributor.affiliationUniversity of Sheffielden_UK
dc.contributor.affiliationUniversity of Sheffielden_UK
dc.contributor.affiliationUniversity of Manchesteren_UK
dc.contributor.affiliationKing's College Londonen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationUniversity of Cambridgeen_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorEccles, Suzanne A|en_UK
local.rioxx.authorAboagye, Eric O|en_UK
local.rioxx.authorAli, Simak|en_UK
local.rioxx.authorAnderson, Annie S|en_UK
local.rioxx.authorArmes, Jo|en_UK
local.rioxx.authorBerditchevski, Fedor|en_UK
local.rioxx.authorBlaydes, Jeremy P|en_UK
local.rioxx.authorBrennan, Keith|en_UK
local.rioxx.authorBrown, Nicola|en_UK
local.rioxx.authorBryant, Helen|en_UK
local.rioxx.authorBundred, Nigel J|en_UK
local.rioxx.authorBurchell, Joy M|en_UK
local.rioxx.authorCampbell, Anna|en_UK
local.rioxx.authorCarroll, Jason S|en_UK
local.rioxx.authorHubbard, Gill|0000-0003-2165-5770en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameBreast Cancer Research 2013.pdfen_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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