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dc.contributor.authorSymon, Andrew-
dc.contributor.authorWilliams, Brian-
dc.contributor.authorAdelasoye, Qadir A-
dc.contributor.authorCheyne, Helen-
dc.description.abstractAims: A discussion of the existence, prevalence and characteristics of the nocebo effect in health care. Background: There is increasing but inconsistent evidence for nocebo effects (the opposite of placebo). Causal mechanisms are believed to be similar to placebo (negative effects result from suggestions of negative clinical outcomes). Risk screening in health care may produce this unintended effect through labelling some patients as high risk. Given health care's almost universal coverage this potentially affects many people. Design: Discussion paper following a scoping review of the existence and frequency of nocebo. Data sources: Literature databases (PsycINFO, MEDLINE, CCTR, CINAHL and EMBASE) searched from inception dates to 2013. Implications for nursing: Significant empirical evidence indicates that negative beliefs may impact on health outcomes (incidence estimates range from 3-27%). The nocebo effect, rooted in the complex interplay between physiological functioning and social factors, appears significantly more common among women and where prior negative knowledge or expectations exist. Pre-existing psychological characteristics (anxiety, neuroses, panic disorder or pessimism) exacerbate it. Conclusion: While the placebo effect is well documented, there has been no systematic attempt to synthesize primary empirical research on the role of nocebo. It is possible that nocebo outcomes may be preventable through careful consideration of information provision and the prior identification of potentially high risk individuals. This paper summarizes the scale and importance of the nocebo effect, its distribution according to a range of social and clinical variables and its known relation to psychological precursors. It identifies important gaps in the research literature.en_UK
dc.relationSymon A, Williams B, Adelasoye QA & Cheyne H (2015) Nocebo and the potential harm of 'high risk' labelling: A scoping review, Journal of Advanced Nursing, 71 (7), pp. 1518-1529.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectbiopsychosocial model of health and illnessen_UK
dc.subjectconceptual modelen_UK
dc.subjectnegative placeboen_UK
dc.subjectnursing theoryen_UK
dc.subjectpsychosocial correlatesen_UK
dc.titleNocebo and the potential harm of 'high risk' labelling: A scoping reviewen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleJournal of Advanced Nursing-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationUniversity of Dundee-
dc.contributor.affiliationNMAHP Research-
dc.contributor.affiliationKing's College London-
dc.contributor.affiliationNMAHP Research-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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