Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21691
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dc.contributor.authorWitard, Oliveren_UK
dc.contributor.authorCocke, Tara Len_UK
dc.contributor.authorFerrando, Arny Aen_UK
dc.contributor.authorWolfe, Robert Ren_UK
dc.contributor.authorTipton, Kevinen_UK
dc.date.accessioned2018-01-18T07:37:22Z-
dc.date.available2018-01-18T07:37:22Z-
dc.date.issued2014-03en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21691-
dc.description.abstractRelative to essential amino acids (EAAs), carbohydrate (CHO) ingestion stimulates a delayed response of net muscle protein balance (NBAL). We investigated if staggered ingestion of CHO and EAA would superimpose the response of NBAL following resistance exercise, thus resulting in maximal anabolic stimulation. Eight recreationally trained subjects completed 2 trials: combined (COMB - drink 1, CHO+EAA; drink 2, placebo) and separated (SEP - drink 1, CHO; drink 2, EAA) post-exercise ingestion of CHO and EAA. Drink 1 was administered 1 h following an acute exercise bout and was followed 1 h later by drink 2. A primed, continuous infusion of l-[ring-13C6]-phenylalanine was combined with femoral arteriovenous sampling and muscle biopsies for the determination of muscle protein kinetics. Arterial amino acid concentrations increased following ingestion of EAA in both conditions. No difference between conditions was observed for phenylalanine delivery to the leg (COMB: 167 ± 23 μmol·min-1·(100 mL leg vol)-1 × 6 h; SEP: 167 ± 21 μmol·min-1·(100 mL leg vol)-1 × 6 h, P > 0.05). In the first hour following ingestion of the drink containing EAA, phenylalanine uptake was 50% greater for the SEP trial than the COMB trial. However, phenylalanine uptake was similar for COMB (110 ± 19 mg) and SEP (117 ± 24 mg) over the 6 h period. These data suggest that whereas separation of CHO and EAA ingestion following exercise may have a transient physiological impact on NBAL, this response is not reflected over a longer period. Thus, separation of CHO and EAA ingestion is unnecessary to optimize post-exercise muscle protein metabolism.en_UK
dc.language.isoenen_UK
dc.publisherCanadian Science Publishingen_UK
dc.relationWitard O, Cocke TL, Ferrando AA, Wolfe RR & Tipton K (2014) Increased net muscle protein balance in response to simultaneous and separate ingestion of carbohydrate and essential amino acids following resistance exercise. Applied Physiology, Nutrition, and Metabolism, 39 (3), pp. 329-339. https://doi.org/10.1139/apnm-2013-0264en_UK
dc.rightsPublisher policy allows this work to be made available in this repository. Published in Applied Physiology, Nutrition, and Metabolism, 2014, 39(3): 329-339, 10.1139/apnm-2013-0264. Copyright NRC Research Press. The published version is available at: http://www.nrcresearchpress.com/doi/abs/10.1139/apnm-2013-0264#.VTop_U90zcsen_UK
dc.subjectnutrient timingen_UK
dc.subjectresistance exercise recoveryen_UK
dc.subjectmuscle protein balanceen_UK
dc.subjectmuscle protein synthesisen_UK
dc.titleIncreased net muscle protein balance in response to simultaneous and separate ingestion of carbohydrate and essential amino acids following resistance exerciseen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1139/apnm-2013-0264en_UK
dc.citation.jtitleApplied Physiology, Nutrition, and Metabolismen_UK
dc.citation.issn1715-5320en_UK
dc.citation.issn1715-5312en_UK
dc.citation.volume39en_UK
dc.citation.issue3en_UK
dc.citation.spage329en_UK
dc.citation.epage339en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.funderGlaxoSmithKlineen_UK
dc.author.emailoliver.witard@stir.ac.uken_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Texas Medical Branchen_UK
dc.contributor.affiliationUniversity of Arkansas for Medical Sciencesen_UK
dc.contributor.affiliationUniversity of Arkansas for Medical Sciencesen_UK
dc.contributor.affiliationSporten_UK
dc.identifier.isiWOS:000331946300008en_UK
dc.identifier.scopusid2-s2.0-84894044161en_UK
dc.identifier.wtid648331en_UK
dc.contributor.orcid0000-0002-5875-8397en_UK
dc.contributor.orcid0000-0002-6545-8122en_UK
dc.date.accepted2014-03-01en_UK
dcterms.dateAccepted2014-03-01en_UK
dc.date.filedepositdate2015-04-24en_UK
dc.relation.funderprojectDose response of muscle protein synthesis to whey protein ingestion relative to lean body mass studyen_UK
dc.relation.funderrefn/aen_UK
rioxxterms.apcnot requireden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorWitard, Oliver|0000-0002-5875-8397en_UK
local.rioxx.authorCocke, Tara L|en_UK
local.rioxx.authorFerrando, Arny A|en_UK
local.rioxx.authorWolfe, Robert R|en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.projectn/a|GlaxoSmithKline|http://dx.doi.org/10.13039/100004330en_UK
local.rioxx.freetoreaddate2015-04-24en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/all-rights-reserved|2015-04-24|en_UK
local.rioxx.filenameWitard et al 13 CHO EAA NBAL FSR APNM.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1715-5312en_UK
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