Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/21539
Full metadata record
DC FieldValueLanguage
dc.contributor.authorJohnson, Chris Fen_UK
dc.contributor.authorDougall, Nadineen_UK
dc.contributor.authorWilliams, Brianen_UK
dc.contributor.authorMacGillivray, Steveen_UK
dc.contributor.authorBuchanan, Alasdair Ien_UK
dc.contributor.authorHassett, Richard Den_UK
dc.date.accessioned2016-12-30T00:05:06Z-
dc.date.available2016-12-30T00:05:06Z-
dc.date.issued2014en_UK
dc.identifier.other210en_UK
dc.identifier.urihttp://hdl.handle.net/1893/21539-
dc.description.abstractBackground Antidepressant prescribing continues to rise. Increased long-term prescribing and higher doses are contributing to current growth; however, patient factors associated with the use of higher doses remain unknown. This study?s aim was to investigate patient factors associated with selective serotonin re-uptake inhibitor (SSRI) prescribed daily dose for depression treatment in general practice. Methods A stratified sample of low to high prescribing practices were selected. Routine individual patient-level data were extracted one practice at a time: September 2009 to January 2011. Patients included were ≥18 years, and prescribed an SSRI for depression. Logistic regression analysis was undertaken to assess individual predictor variables on SSRI daily dose by standard therapeutic dose versus higher dose, as SSRIs demonstrate flat dose response curves for depression treatment. Predictor variables included: age, gender, deprivation, co-morbidity, smoking status, being prescribed the same SSRI for ≥2 years, and patients? general practice. For a subgroup of patients a second sub-group analysis included long-term benzodiazepine and/or z-hypnotic (B&Z) as a predictor variable. Results Inter-practice SSRI prescribing varied significantly; practice point prevalence ranged from 2.5% (94/3697) to 11.9% (359/3007) of the practice population ≥18 years old; median 7.3% (250/3421) (χ 2 = 2277.2, df = 10, p < 0.001). Overall point prevalence was 6.3% (3518/52575), with 5.8% (3066/52575) prescribed SSRIs for depression of whom 84.7% (2596/3066) had data for regression analysis. Higher SSRI doses were significantly associated with, in descending order of magnitude, individual practice attended, being prescribed the same SSRI for ≥2 years (Odds Ratio (OR) 1.80, 95% CI 1.49 to 2.17, p < 0.001) and living in a more deprived area (OR 1.55, 95% CI 1.11 to 2.16, p = 0.009). Higher SSRI doses in the B&Z subgroup were significantly associated with individual practice attended, being prescribed a long-term B&Z (OR 2.05 95% CI 1.47 to 2.86, p < 0.001) and being prescribed the same SSRI for ≥2 years (OR 1.94, 95% CI 1.53 to 2.47, p < 0.001). Conclusion Higher SSRI doses for depression were associated with practice attended and being prescribed the same antidepressant for ≥2 years. As long-term antidepressant use increases, the use of higher doses may further contribute to prescribing growth.en_UK
dc.language.isoenen_UK
dc.publisherBioMed Centralen_UK
dc.relationJohnson CF, Dougall N, Williams B, MacGillivray S, Buchanan AI & Hassett RD (2014) Patient factors associated with SSRI dose for depression treatment in general practice: a primary care cross sectional study. BMC Family Practice, 115, Art. No.: 210. https://doi.org/10.1186/s12875-014-0210-9en_UK
dc.rights© Johnson et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/en_UK
dc.subjectFamily practiceen_UK
dc.subjectChronic diseaseen_UK
dc.subjectDepressionen_UK
dc.subjectAntidepressive agentsen_UK
dc.subjectBenzodiazepinesen_UK
dc.titlePatient factors associated with SSRI dose for depression treatment in general practice: a primary care cross sectional studyen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1186/s12875-014-0210-9en_UK
dc.identifier.pmid25540076en_UK
dc.citation.jtitleBMC Family Practiceen_UK
dc.citation.issn1471-2296en_UK
dc.citation.volume115en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.author.emailnadine.dougall@stir.ac.uken_UK
dc.citation.date24/12/2014en_UK
dc.contributor.affiliationFHSS Management and Supporten_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationNMAHPen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationGlasgow City CHPen_UK
dc.contributor.affiliationNHS Greater Glasgow & Clydeen_UK
dc.identifier.isiWOS:000209590800001en_UK
dc.identifier.scopusid2-s2.0-84923868007en_UK
dc.identifier.wtid602828en_UK
dc.contributor.orcid0000-0002-6006-6605en_UK
dc.contributor.orcid0000-0003-3462-6960en_UK
dc.contributor.orcid0000-0003-0000-4354en_UK
dc.date.accepted2014-12-12en_UK
dcterms.dateAccepted2014-12-12en_UK
dc.date.filedepositdate2015-02-24en_UK
rioxxterms.apcpaiden_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionAMen_UK
local.rioxx.authorJohnson, Chris F|0000-0002-6006-6605en_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.authorWilliams, Brian|0000-0003-0000-4354en_UK
local.rioxx.authorMacGillivray, Steve|en_UK
local.rioxx.authorBuchanan, Alasdair I|en_UK
local.rioxx.authorHassett, Richard D|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2015-02-24en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by/4.0/|2015-02-24|en_UK
local.rioxx.filenameChris Johnson BMC Family Practice.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1471-2296en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

Files in This Item:
File Description SizeFormat 
Chris Johnson BMC Family Practice.pdfFulltext - Accepted Version207.13 kBAdobe PDFView/Open


This item is protected by original copyright



A file in this item is licensed under a Creative Commons License Creative Commons

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved https://creativecommons.org/publicdomain/zero/1.0/

If you believe that any material held in STORRE infringes copyright, please contact library@stir.ac.uk providing details and we will remove the Work from public display in STORRE and investigate your claim.