Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Effects of central sympathetic inhibition on heart rate variability during steady-state exercise in healthy humans
Author(s): De Vito, Giuseppe
Galloway, S D
Nimmo, Myra A
Maas, Peter
McMurray, John J V
Contact Email:
Keywords: exercise
heart rate variability
Poincaré plot
Issue Date: Jan-2002
Date Deposited: 16-Feb-2015
Citation: De Vito G, Galloway SD, Nimmo MA, Maas P & McMurray JJV (2002) Effects of central sympathetic inhibition on heart rate variability during steady-state exercise in healthy humans. Clinical Physiology and Functional Imaging, 22 (1), pp. 32-38.
Abstract: The profound reduction in heart rate variability (HRV) that occurs during exercise is thought to be, at least in part, the result of sympathetic nervous system activation. Moxonidine is a centrally acting anti-sympathetic drug, which suppresses sympathetic nervous system outflow by stimulation of central imidazoline receptors located in the rostral ventro-lateral medulla. This study was designed to investigate the combined effects of central sympathetic inhibition with moxonidine and steady-state dynamic exercise on HRV. Ten normal males participated in a double-blind cross-over study, taking either placebo or 0·4 mg of moxonidine. The subjects were studied at rest and during steady-state exercise. HRV was measured considering both time and frequency domain parameters. As a non-linear measure, the Poincaré scatter-plot was measured and analysed quantitatively. Ventilation and gas exchange were also measured during exercise. In addition, plasma catecholamines were measured at rest and during exercise. The only parameter changed, at rest, by moxonidine was the blood pressure which was reduced. During exercise, moxonidine reduced plasma noradrenaline (NA), compared with the placebo (P<0·01). The only change observed in HRV during exercise was a significant reduction of the continuous long-term standard deviation (SD2) of the Poincaré scatter-plot of the R-R interval (P<0·05). However, the potential and prognostic significance of this result needs to be further assessed.
DOI Link: 10.1046/j.1475-097X.2002.00395.x
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Licence URL(s):

Files in This Item:
File Description SizeFormat 
Galloway_CPFI_2002.pdfFulltext - Published Version372.28 kBAdobe PDFUnder Embargo until 3000-01-01    Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.