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dc.contributor.authorSmith, Scott M-
dc.contributor.authorCastaneda-Sceppa, Carmen-
dc.contributor.authorO'Brien, Kimberly O-
dc.contributor.authorAbrams, Steven A-
dc.contributor.authorGillman, Patricia L-
dc.contributor.authorBrooks, Naomi-
dc.contributor.authorCloutier, Gregory J-
dc.contributor.authorHeer, Martina-
dc.contributor.authorZwart, Sara R-
dc.contributor.authorWastney, Meryl E-
dc.description.abstractSUMMARY: We assessed the potential for countermeasures to lessen the loss of bone calcium during bed rest. Subjects ingested less calcium during bed rest, and with artificial gravity, they also absorbed less calcium. With exercise, they excreted less calcium. To retain bone during bed rest, calcium intake needs to be maintained. INTRODUCTION: This study aims to assess the potential for artificial gravity (AG) and exercise (EX) to mitigate loss of bone calcium during space flight. METHODS: We performed two studies: (1) a 21-day bed rest (BR) study with subjects receiving 1 h/day AG (n = 8) or no AG (n = 7) and (2) a 28-day BR study with 1 h/day resistance EX (n = 10) or no EX (n = 3). In both studies, stable isotopes of Ca were administered orally and intravenously, at baseline and after 10 days of BR, and blood, urine, and feces were sampled for up to 14 days post dosing. Tracers were measured using thermal ionization mass spectrometry. Data were analyzed by compartmental modeling. RESULTS: Less Ca was absorbed during BR, resulting in lower Ca balance in BR+AG (-6.04 ± 3.38 mmol/day, P = 0.023). However, Ca balance did not change with BR+EX, even though absorbed Ca decreased and urinary Ca excretion increased, because endogenous excretion decreased, and there was a trend for increased bone deposition (P = 0.06). Urinary N-telopeptide excretion increased in controls during BR, but not in the EX group. Markers of bone formation were not different between treatment groups for either study. Ca intake decreased during BR (by 5.4 mmol/day in the AG study and 2.8 mmol/day in the EX study), resulting in lower absorbed Ca. CONCLUSIONS: During BR (or space flight), Ca intake needs to be maintained or even increased with countermeasures such as exercise, to enable maintenance of bone Ca.en_UK
dc.relationSmith SM, Castaneda-Sceppa C, O'Brien KO, Abrams SA, Gillman PL, Brooks N, Cloutier GJ, Heer M, Zwart SR & Wastney ME (2014) Calcium kinetics during bed rest with artificial gravity and exercise countermeasures, Osteoporosis International, 25 (9), pp. 2237-2244.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectBiochemical markers of bone turnoveren_UK
dc.subjectSpace flighten_UK
dc.titleCalcium kinetics during bed rest with artificial gravity and exercise countermeasuresen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleOsteoporosis International-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationNational Aeronautics and Space Administration (NASA)-
dc.contributor.affiliationNortheastern University (US)-
dc.contributor.affiliationCornell University-
dc.contributor.affiliationBaylor College of Medicine-
dc.contributor.affiliationEnterprise Advisory Services, Inc (EASI)-
dc.contributor.affiliationNortheastern University (US)-
dc.contributor.affiliationUniversity of Bonn-
dc.contributor.affiliationUniversities Space Research Association (USRA)-
dc.contributor.affiliationMetabolic Modeling Services Ltd-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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