|Appears in Collections:||Faculty of Health Sciences and Sport Journal Articles|
|Peer Review Status:||Refereed|
|Title:||Type 2 diabetes mellitus and obesity in young adults: The extreme phenotype with early cardiovascular dysfunction|
|Author(s):||Wilmot, Emma G|
Khan, Jamal N
Bodicoat, Danielle H
Kuijer, Joost P A
Gray, Laura J
Nimmo, Myra A
Mccann, Gerry P
Davies, Melanie J
|Citation:||Wilmot EG, Leggate M, Khan JN, Yates T, Gorely T, Bodicoat DH, Khunti K, Kuijer JPA, Gray LJ, Singh A, Clarysse P, Croisille P, Nimmo MA, Mccann GP & Davies MJ (2014) Type 2 diabetes mellitus and obesity in young adults: The extreme phenotype with early cardiovascular dysfunction. Diabetic Medicine, 31 (7), pp. 794-798. https://doi.org/10.1111/dme.12431|
|Abstract:||Aim: A pilot study to phenotype young adults (< 40 years) with Type 2 diabetes mellitus. Methods: Twenty people with Type 2 diabetes (aged 18-40 years), 10 lean and 10 obese control subjects underwent detailed assessment, including tagged cardiac magnetic resonance imaging, inflammatory proteins, lipids, vitamin D and maximal oxygen uptake. Outcomes were compared between the group with Type 2 diabetes and the control group. Results: Mean (standard deviation) age, Type 2 diabetes duration and BMI in the group with Type 2 diabetes were 31.8 (6.6) years, 4.7 (4.0) years and 33.9 (5.8) kg/m2 respectively. Compared with lean control subjects, those with Type 2 diabetes had more deleterious profiles of hyperlipidaemia, vitamin D deficiency, inflammation and maximal oxygen uptake relative to body mass. However, there was no difference between the group with Type 2 diabetes and the obese control group. The group with Type 2 diabetes had a higher left ventricular mass and a trend towards concentric remodelling compared with the lean control group (P = 0.002, P = 0.052) but not the obese control group (P > 0.05). Peak early diastolic strain rate was reduced in the group with Type 2 diabetes [1.51 (0.24)/s] compared with the lean control [1.97 (0.34)/s, P = 0.001] and obese control [1.78 (0.39)/s, P = 0.042] group. Conclusions: Young adults with Type 2 diabetes and those with obesity have similar adverse cardiovascular risk profiles, higher left ventricular mass and a trend towards left ventricular concentric remodelling. In addition, those with Type 2 diabetes demonstrate diastolic dysfunction, a known risk marker for future heart failure and mortality.|
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