Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/20890
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dc.contributor.authorKilgour, Alixe H M-
dc.contributor.authorGallagher, Iain J-
dc.contributor.authorMacLullich, Alasdair M J-
dc.contributor.authorAndrew, Ruth-
dc.contributor.authorGray, Calum-
dc.contributor.authorHyde, Philippa-
dc.contributor.authorWackerhage, Henning-
dc.contributor.authorHusi, Holger-
dc.contributor.authorRoss, James A-
dc.contributor.authorStarr, John M-
dc.contributor.authorChapman, Karen E-
dc.contributor.authorFearon, Kenneth C H-
dc.contributor.authorWalker, Brian R-
dc.contributor.authorGreig, Carolyn-
dc.date.accessioned2016-10-08T22:39:13Z-
dc.date.available2016-10-08T22:39:13Z-
dc.date.issued2013-12-
dc.identifier.othere84057-
dc.identifier.urihttp://hdl.handle.net/1893/20890-
dc.description.abstractBACKGROUND Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR) signaling by increased expression of either GR or the GC-amplifying enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11βHSD1) in muscle. METHODS There were 82 participants; group 1 comprised 33 older men (mean age 70.2 years, SD 4.4) and 19 younger men (22.2 years, 1.7) and group 2 comprised 16 older men (79.1 years, 3.4) and 14 older women (80.1 years, 3.7). We measured muscle strength, mid-thigh cross-sectional area, fasting morning plasma cortisol, quadriceps muscle GR and 11βHSD1 mRNA, and urinary glucocorticoid metabolites. Data were analysed using multiple linear regression adjusting for age, gender and body size. RESULTS Muscle strength and size were not associated with plasma cortisol, total urinary glucocorticoids or the ratio of urinary 5β-tetrahydrocortisol +5α-tetrahydrocortisol to tetrahydrocortisone (an index of systemic 11βHSD activity). Muscle strength was associated with 11βHSD1 mRNA levels (β -0.35, p = 0.04), but GR mRNA levels were not significantly associated with muscle strength or size. CONCLUSION Although circulating levels of GC are not associated with muscle strength or size in either gender, increased cortisol generation within muscle by 11βHSD1 may contribute to loss of muscle strength with age, a key component of sarcopenia. Inhibition of 11βHSD1 may have therapeutic potential in sarcopenia.en_UK
dc.language.isoen-
dc.publisherPublic Library of Science-
dc.relationKilgour AHM, Gallagher IJ, MacLullich AMJ, Andrew R, Gray C, Hyde P, Wackerhage H, Husi H, Ross JA, Starr JM, Chapman KE, Fearon KCH, Walker BR & Greig C (2013) Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing, PLoS ONE, 8 (12), Art. No.: e84057.-
dc.rights© 2013 Kilgour et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.-
dc.titleIncreased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageingen_UK
dc.typeJournal Articleen_UK
dc.identifier.doihttp://dx.doi.org/10.1371/journal.pone.0084057-
dc.identifier.pmid24391882-
dc.citation.jtitlePLoS ONE-
dc.citation.issn1932-6203-
dc.citation.volume8-
dc.citation.issue12-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emaili.j.gallagher@stir.ac.uk-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Aberdeen-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.contributor.affiliationUniversity of Edinburgh-
dc.identifier.isi000329323900025-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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