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dc.contributor.authorJohnson, Chris Fen_UK
dc.contributor.authorMacdonald, Hector Jen_UK
dc.contributor.authorAtkinson, Paulineen_UK
dc.contributor.authorBuchanan, Alasdair Ien_UK
dc.contributor.authorDownes, Noreenen_UK
dc.contributor.authorDougall, Nadineen_UK
dc.description.abstractBackground: Antidepressant prescribing continues to rise. Contributing factors are increased long-term prescribing and possibly the use of higher selective serotonin re-uptake inhibitor (SSRI) doses. Aim: To review general practice patients prescribed the same antidepressant long-term (≥2 years) and evaluate prescribing and management pre and post-review. Design and setting: Prospective observational cohort study using routine data from 78 urban general practices, Scotland. Method: All patients prescribed antidepressants (excluding amitriptyline) for ≥2 years were identified from records November 2009 to March 2010. GPs selected patients for face-to-face review of clinical condition and medication, December 2009 to September 2010. Pre- and post-review data were collected; average antidepressant doses and changes in prescribed daily doses were calculated. Onward referral to support services was recorded. Results: 8.6% (33 312/388 656) of all registered patients were prescribed an antidepressant, 47.1% (15 689) were defined as long-term users and 2849 (18.2%) were reviewed. 811 (28.5%) patients reviewed had a change in antidepressant therapy: 7.0% stopped, 12.8% reduced dose, 5.3% increased dose, and 3.4% changed antidepressant, resulting in 9.5% (95% CI = 9.1% to 9.8% P less than 0.001) reduction in prescribed daily dose and 8.1% reduction in prescribing costs. 6.3% were referred onwards, half to NHS Mental Health Services. Pre-review SSRI doses were 10-30% higher than previously reported. Conclusion: Almost half of all people prescribed antidepressants were long-term users. Appropriate reductions in prescribing can be achieved by reviewing patients. Higher SSRI doses may be contributing to current antidepressant growth.en_UK
dc.publisherRoyal College of General Practitionersen_UK
dc.relationJohnson CF, Macdonald HJ, Atkinson P, Buchanan AI, Downes N & Dougall N (2012) Reviewing long-term antidepressants can reduce drug burden: a prospective observational cohort study. British Journal of General Practice, 62 (604), pp. 584-585.
dc.rightsThe publisher has granted permission for use of this work in this Repository. Published in British Journal of General Practice by Royal College of General Practitioners. Please cite as: Chris F Johnson, Hector J Macdonald, Pauline Atkinson. Reviewing long-term antidepressants can reduce drug burden: a prospective observational cohort study. Br J Gen Pract 2012; Nov;62(604): 584-5. Article can be accessed online at:
dc.subjectdrug therapyen_UK
dc.subjectprimary careen_UK
dc.titleReviewing long-term antidepressants can reduce drug burden: a prospective observational cohort studyen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleBritish Journal of General Practiceen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationFHSS Management and Supporten_UK
dc.contributor.affiliationPort Glasgow Health Centreen_UK
dc.contributor.affiliationGreenock Health Centreen_UK
dc.contributor.affiliationGlasgow City CHPen_UK
dc.contributor.affiliationQueens Park House, Glasgowen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorJohnson, Chris F|0000-0002-6006-6605en_UK
local.rioxx.authorMacdonald, Hector J|en_UK
local.rioxx.authorAtkinson, Pauline|en_UK
local.rioxx.authorBuchanan, Alasdair I|en_UK
local.rioxx.authorDownes, Noreen|en_UK
local.rioxx.authorDougall, Nadine|0000-0003-3462-6960en_UK
local.rioxx.projectInternal Project|University of Stirling|
local.rioxx.filenameJohnson et al BJGP 2012.pdfen_UK
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