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dc.contributor.authorReynolds, Rebecca Men_UK
dc.contributor.authorWalker, Brian Ren_UK
dc.contributor.authorHaw, Sallyen_UK
dc.contributor.authorNewby, David Een_UK
dc.contributor.authorMackay, Daniel Fen_UK
dc.contributor.authorCobbe, Stuart Men_UK
dc.contributor.authorPell, Alastair C Hen_UK
dc.contributor.authorFischbacher, Colinen_UK
dc.contributor.authorPringle, Stuart Den_UK
dc.contributor.authorMurdoch, Daviden_UK
dc.contributor.authorDunn, Franken_UK
dc.contributor.authorOldroyd, Keith Gen_UK
dc.contributor.authorMacIntyre, Paul Den_UK
dc.contributor.authorO'Rourke, Brianen_UK
dc.contributor.authorPell, Jillen_UK
dc.description.abstractObjective: To determine whether low serum cortisol concentrations are associated with adverse prognosis in patients with acute myocardial infarction. Low serum cortisol concentrations have been associated with adverse prognosis in critical illness of diverse etiology. Design: Nested case-control study. Setting: Prospective cohort study of consecutive patients admitted with acute myocardial infarction to nine Scottish hospitals. Patients: A total of 100 patients who survived 30 days (controls) and 100 patients who died within 30 days (cases). Measurements and Main Results: Admission cortisol concentrations were lower in patients who died than those who survived (median, 1189 nmol/L vs. 1355 nmol/L; p < .001). A cortisol concentration in the bottom quartile (<1136 nmol/L) was a strong predictor of death within 30 days and remained so after adjustment for age and cardiac troponin concentration (adjusted odds ratio, 8.78; 95% confidence interval, 3.09-24.96; p < .001). Conclusions: Patients who mount a lesser cortisol stress response to acute myocardial infarction have a poorer early prognosis.en_UK
dc.publisherSociety of Critical Care Medicine and Lippincott Williams & Wilkinsen_UK
dc.relationReynolds RM, Walker BR, Haw S, Newby DE, Mackay DF, Cobbe SM, Pell ACH, Fischbacher C, Pringle SD, Murdoch D, Dunn F, Oldroyd KG, MacIntyre PD, O'Rourke B & Pell J (2010) Low serum cortisol predicts early death after acute myocardial infarction. Critical Care Medicine, 38 (3), pp. 973-975.
dc.rightsPublisher policy allows this work to be made available in this repository. This is a non-final version of an article published in final form in Critical Care Medicine: March 2010 - Volume 38 - Issue 3 - pp 973-975, doi: 10.1097/CCM.0b013e3181cdf6de by the Society of Critical Care Medicine and Lippincott Williams & Wilkins. The original publication is available at:
dc.subjectacute myocardial infarctionen_UK
dc.subjectadrenal insufficiencyen_UK
dc.subjectnested case-control studyen_UK
dc.titleLow serum cortisol predicts early death after acute myocardial infarctionen_UK
dc.typeJournal Articleen_UK
dc.citation.jtitleCritical Care Medicineen_UK
dc.type.statusAM - Accepted Manuscripten_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationUniversity of Edinburghen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationGlasgow Royal Infirmaryen_UK
dc.contributor.affiliationMonksland Hospitalen_UK
dc.contributor.affiliationPublic Health Information Services Divisionen_UK
dc.contributor.affiliationUniversity of Dundeeen_UK
dc.contributor.affiliationSouthern General Hospitalen_UK
dc.contributor.affiliationStobhill Hospitalen_UK
dc.contributor.affiliationWest of Scotland Heart and Lung Centreen_UK
dc.contributor.affiliationRoyal Alexandra Hospital (NHS Greater Glasgow & Clyde)en_UK
dc.contributor.affiliationHairmyres Hospital, East Kilbrideen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorReynolds, Rebecca M|en_UK
local.rioxx.authorWalker, Brian R|en_UK
local.rioxx.authorHaw, Sally|0000-0001-7844-0362en_UK
local.rioxx.authorNewby, David E|en_UK
local.rioxx.authorMackay, Daniel F|en_UK
local.rioxx.authorCobbe, Stuart M|en_UK
local.rioxx.authorPell, Alastair C H|en_UK
local.rioxx.authorFischbacher, Colin|en_UK
local.rioxx.authorPringle, Stuart D|en_UK
local.rioxx.authorMurdoch, David|en_UK
local.rioxx.authorDunn, Frank|en_UK
local.rioxx.authorOldroyd, Keith G|en_UK
local.rioxx.authorMacIntyre, Paul D|en_UK
local.rioxx.authorO'Rourke, Brian|en_UK
local.rioxx.authorPell, Jill|en_UK
local.rioxx.projectInternal Project|University of Stirling|
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