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dc.contributor.authorHastie, Claire Een_UK
dc.contributor.authorHaw, Sallyen_UK
dc.contributor.authorPell, Jillen_UK
dc.description.abstractC-reactive protein (CRP) levels predict coronary heart disease (CHD) risk. Levels are raised among smokers, but the effect of smoking cessation is unclear. Exposure to secondhand smoke (SHS) may be a confounder. Lifetime smoking exposure may have a dose effect on CRP among smokers, but it is unclear if this persists after cessation. We analyzed cross-sectional data on 4,072 adults recruited to a Scotland-wide population health survey who did not have CHD and were not on nicotine replacement therapy. CRP fell with time from cessation but was still raised up to 5 years after adjustment for case-mix (p<.001). SHS exposure was greater among ex-smokers than never-smokers (median cotinine 0.5 ng/ml vs. 0.4 ng/ml, p<.001) but did not explain the difference. Among smokers, there was a dose relationship between pack years and CRP on both univariate, F(4,1279) = 31.841, p<.001, and multivariate, F(4,1085) = 3.499, p = .008, analysis. Among ex-smokers there was also a dose relationship between pack-years and CRP, F(4,751) = 14.108, p<.001, which was independent of time from cessation and case-mix, F(4,466) = 3.744, p = .005. That CRP does not fall to normal levels immediately and that lifetime smoking exposure continues to impact on CRP levels post cessation suggest that CRP is not raised as a direct effect of cigarette smoke but rather via a secondary mechanism, such as tissue damage causing an inflammatory stimulus. Our results reinforce the need to encourage smoking cessation as early as possible.en_UK
dc.publisherOxford University Pressen_UK
dc.relationHastie CE, Haw S & Pell J (2008) Impact of smoking cessation and lifetime exposure on C-reactive protein. Nicotine and Tobacco Research, 10 (4), pp. 637-642.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.titleImpact of smoking cessation and lifetime exposure on C-reactive proteinen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Haw_Impact_of_smoking_cessation_and_lifetime_exposure_on_C_reactive_protein.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleNicotine and Tobacco Researchen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationBritish Heart Foundationen_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorHastie, Claire E|en_UK
local.rioxx.authorHaw, Sally|0000-0001-7844-0362en_UK
local.rioxx.authorPell, Jill|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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