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DC Field | Value | Language |
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dc.contributor.author | Hastie, Claire E | en_UK |
dc.contributor.author | Haw, Sally | en_UK |
dc.contributor.author | Pell, Jill | en_UK |
dc.date.accessioned | 2014-09-12T17:19:46Z | - |
dc.date.available | 2014-09-12T17:19:46Z | - |
dc.date.issued | 2008-04 | en_UK |
dc.identifier.uri | http://hdl.handle.net/1893/16657 | - |
dc.description.abstract | C-reactive protein (CRP) levels predict coronary heart disease (CHD) risk. Levels are raised among smokers, but the effect of smoking cessation is unclear. Exposure to secondhand smoke (SHS) may be a confounder. Lifetime smoking exposure may have a dose effect on CRP among smokers, but it is unclear if this persists after cessation. We analyzed cross-sectional data on 4,072 adults recruited to a Scotland-wide population health survey who did not have CHD and were not on nicotine replacement therapy. CRP fell with time from cessation but was still raised up to 5 years after adjustment for case-mix (p<.001). SHS exposure was greater among ex-smokers than never-smokers (median cotinine 0.5 ng/ml vs. 0.4 ng/ml, p<.001) but did not explain the difference. Among smokers, there was a dose relationship between pack years and CRP on both univariate, F(4,1279) = 31.841, p<.001, and multivariate, F(4,1085) = 3.499, p = .008, analysis. Among ex-smokers there was also a dose relationship between pack-years and CRP, F(4,751) = 14.108, p<.001, which was independent of time from cessation and case-mix, F(4,466) = 3.744, p = .005. That CRP does not fall to normal levels immediately and that lifetime smoking exposure continues to impact on CRP levels post cessation suggest that CRP is not raised as a direct effect of cigarette smoke but rather via a secondary mechanism, such as tissue damage causing an inflammatory stimulus. Our results reinforce the need to encourage smoking cessation as early as possible. | en_UK |
dc.language.iso | en | en_UK |
dc.publisher | Oxford University Press | en_UK |
dc.relation | Hastie CE, Haw S & Pell J (2008) Impact of smoking cessation and lifetime exposure on C-reactive protein. Nicotine and Tobacco Research, 10 (4), pp. 637-642. https://doi.org/10.1080/14622200801978722 | en_UK |
dc.rights | The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study. | en_UK |
dc.rights.uri | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved | en_UK |
dc.title | Impact of smoking cessation and lifetime exposure on C-reactive protein | en_UK |
dc.type | Journal Article | en_UK |
dc.rights.embargodate | 2999-12-31 | en_UK |
dc.rights.embargoreason | [Haw_Impact_of_smoking_cessation_and_lifetime_exposure_on_C_reactive_protein.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work. | en_UK |
dc.identifier.doi | 10.1080/14622200801978722 | en_UK |
dc.identifier.pmid | 18418786 | en_UK |
dc.citation.jtitle | Nicotine and Tobacco Research | en_UK |
dc.citation.issn | 1469-994X | en_UK |
dc.citation.issn | 1462-2203 | en_UK |
dc.citation.volume | 10 | en_UK |
dc.citation.issue | 4 | en_UK |
dc.citation.spage | 637 | en_UK |
dc.citation.epage | 642 | en_UK |
dc.citation.publicationstatus | Published | en_UK |
dc.citation.peerreviewed | Refereed | en_UK |
dc.type.status | VoR - Version of Record | en_UK |
dc.author.email | s.j.haw@stir.ac.uk | en_UK |
dc.contributor.affiliation | British Heart Foundation | en_UK |
dc.contributor.affiliation | Health Sciences Research - Stirling - LEGACY | en_UK |
dc.contributor.affiliation | University of Glasgow | en_UK |
dc.identifier.isi | WOS:000255416600009 | en_UK |
dc.identifier.scopusid | 2-s2.0-42449161515 | en_UK |
dc.identifier.wtid | 727464 | en_UK |
dc.contributor.orcid | 0000-0001-7844-0362 | en_UK |
dc.date.accepted | 2007-07-23 | en_UK |
dcterms.dateAccepted | 2007-07-23 | en_UK |
dc.date.filedepositdate | 2013-09-16 | en_UK |
rioxxterms.type | Journal Article/Review | en_UK |
rioxxterms.version | VoR | en_UK |
local.rioxx.author | Hastie, Claire E| | en_UK |
local.rioxx.author | Haw, Sally|0000-0001-7844-0362 | en_UK |
local.rioxx.author | Pell, Jill| | en_UK |
local.rioxx.project | Internal Project|University of Stirling|https://isni.org/isni/0000000122484331 | en_UK |
local.rioxx.freetoreaddate | 2999-12-31 | en_UK |
local.rioxx.licence | http://www.rioxx.net/licenses/under-embargo-all-rights-reserved|| | en_UK |
local.rioxx.filename | Haw_Impact_of_smoking_cessation_and_lifetime_exposure_on_C_reactive_protein.pdf | en_UK |
local.rioxx.filecount | 1 | en_UK |
local.rioxx.source | 1462-2203 | en_UK |
Appears in Collections: | Faculty of Health Sciences and Sport Journal Articles |
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Haw_Impact_of_smoking_cessation_and_lifetime_exposure_on_C_reactive_protein.pdf | Fulltext - Published Version | 263.86 kB | Adobe PDF | Under Permanent Embargo Request a copy |
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