Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12963
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dc.contributor.authorMoran, Colin Neilen_UK
dc.contributor.authorBarwell, Nicholas Den_UK
dc.contributor.authorMalkova, Daliaen_UK
dc.contributor.authorCleland, Stephen Jen_UK
dc.contributor.authorMcPhee, Ianen_UK
dc.contributor.authorPackard, Chris Jen_UK
dc.contributor.authorZammit, Victor Aen_UK
dc.contributor.authorGill, Jason M Ren_UK
dc.date.accessioned2016-10-20T00:25:46Z-
dc.date.available2016-10-20T00:25:46Z-
dc.date.issued2011-02en_UK
dc.identifier.urihttp://hdl.handle.net/1893/12963-
dc.description.abstractDaughters of diabetes patients have lower insulin sensitivity than women with no diabetes family history, but increase insulin sensitivity to a greater extent with exercise training. This study aimed to determine whether differences in circulating concentrations of adiponectin and leptin, and adipose tissue expression of their genes and receptors played a role. Women offspring of patients with type 2 diabetes mellitus (n = 34; age, 35.6 ± 7.0 years; body mass index, 28.1 ± 5.1 kg/m2) and matched controls with no diabetes family history (n = 36; age, 33.6 ± 6.1 years; body mass index, 27.3 ± 4.7 kg/m2) participated. Blood and abdominal subcutaneous adipose tissue samples were obtained at baseline and after a controlled 7-week endurance-type exercise intervention (sessions were performed at 65%-80% of maximum heart rate). At baseline, no significant differences were observed between groups in circulating leptin or adiponectin concentrations, or expression of their genes or receptors. In response to exercise, plasma leptin decreased more in offspring than controls (-32.2% vs -7.3%, P = .005 for interaction); and the long isoform of the leptin receptor messenger RNA (mRNA) increased significantly only in the offspring (+39.4%, P = .026 vs +7.7%, P = .892). Leptin mRNA decreased similarly in both groups (-24.7% vs -25.0%, P less than .05 for both). Furthermore, changes in plasma leptin (r = -0.432, P less than .001) and leptin mRNA (r = -0.298, P = .019) correlated significantly with changes in insulin sensitivity. Plasma adiponectin decreased similarly in both groups (-12.1% vs -15.2%, P less than .01 for both), but no significant changes were observed in adiponectin-related gene expression. This work shows that exercise training has differing effects on leptin-related variables between women with and without a diabetes family history and suggests that these molecular differences may contribute to the differential effects of exercise training on insulin sensitivity between these 2 groups.en_UK
dc.language.isoenen_UK
dc.publisherElsevieren_UK
dc.relationMoran CN, Barwell ND, Malkova D, Cleland SJ, McPhee I, Packard CJ, Zammit VA & Gill JMR (2011) Effects of Diabetes Family History and Exercise Training on the expression of Adiponectin and Leptin and their Receptors. Metabolism: Clinical and Experimental, 60 (2), pp. 206-214. https://doi.org/10.1016/j.metabol.2009.12.026en_UK
dc.rightsThis article is open-access. Open access publishing allows free access to and distribution of published articles where the author retains copyright of their work by employing a Creative Commons attribution licence. Proper attribution of authorship and correct citation details should be given.en_UK
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/en_UK
dc.titleEffects of Diabetes Family History and Exercise Training on the expression of Adiponectin and Leptin and their Receptorsen_UK
dc.typeJournal Articleen_UK
dc.identifier.doi10.1016/j.metabol.2009.12.026en_UK
dc.citation.jtitleMetabolismen_UK
dc.citation.issn0026-0495en_UK
dc.citation.volume60en_UK
dc.citation.issue2en_UK
dc.citation.spage206en_UK
dc.citation.epage214en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailcolin.moran@stir.ac.uken_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationScottish Biomedical Ltden_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Warwicken_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.identifier.isiWOS:000286955800007en_UK
dc.identifier.scopusid2-s2.0-78751645163en_UK
dc.identifier.wtid784833en_UK
dc.contributor.orcid0000-0001-6226-8131en_UK
dcterms.dateAccepted2011-02-28en_UK
dc.date.filedepositdate2013-05-17en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMoran, Colin Neil|0000-0001-6226-8131en_UK
local.rioxx.authorBarwell, Nicholas D|en_UK
local.rioxx.authorMalkova, Dalia|en_UK
local.rioxx.authorCleland, Stephen J|en_UK
local.rioxx.authorMcPhee, Ian|en_UK
local.rioxx.authorPackard, Chris J|en_UK
local.rioxx.authorZammit, Victor A|en_UK
local.rioxx.authorGill, Jason M R|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate2013-05-17en_UK
local.rioxx.licencehttp://creativecommons.org/licenses/by-nc-nd/3.0/|2013-05-17|en_UK
local.rioxx.filenameMoran-etal-Metabolism-2011.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0026-0495en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles



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