Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12959
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dc.contributor.authorMoran, Colin Neil-
dc.contributor.authorVassilopoulos, Christos-
dc.contributor.authorTsiokanos, Athanasios-
dc.contributor.authorJamurtas, Athanasios Z-
dc.contributor.authorBailey, Mark E S-
dc.contributor.authorMontgomery, Hugh-
dc.contributor.authorWilson, Richard H-
dc.contributor.authorPitsiladis, Yannis P-
dc.date.accessioned2016-08-26T02:46:23Z-
dc.date.issued2006-03-
dc.identifier.urihttp://hdl.handle.net/1893/12959-
dc.description.abstractGenetic variation in the human Angiotensin I-Converting Enzyme (ACE) gene has been associated with many heritable traits, including physical performance. Herein we report the results of a study of several physical, physiological and skill parameters and lifestyle in 1027 teenage Greeks. We show that there is a strong association (P less than 0.001) between the ACE I/D (insertion/deletion) polymorphism and both handgrip strength and vertical jump in females, homozygotes for the I-allele exhibiting higher performance-related phenotype scores, accounting for up to 4.5% of the phenotypic variance. The association is best explained by a model in which the D-allele is dominant, with the mean phenotypic value in the I/D heterozygotes being close to that of the mean of the DD homozygotes. The association acts across the phenotype distribution in a classical polygenic manner. Other polymorphisms that define major ACE haplotypes in European populations (rs4424958, rs4311) show weaker associations with these performance-related phenotypes than does I/D. Similarly, diplotypes defined by these polymorphisms do not explain significantly larger amounts of the variance than I/D alone. As ACE I/D is the polymorphism most strongly associated with circulating ACE activity in European populations, we propose that the functional allelic differences that influence ACE activity also mediate the associations with the performance-related phenotypes studied here.en_UK
dc.language.isoen-
dc.publisherNature Publishing Group-
dc.relationMoran CN, Vassilopoulos C, Tsiokanos A, Jamurtas AZ, Bailey MES, Montgomery H, Wilson RH & Pitsiladis YP (2006) The associations of ACE polymorphisms with physical, physiological and skill parameters in adolescents, European Journal of Human Genetics, 14 (3), pp. 332-339.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectangiotensin I-converting enzymeen_UK
dc.subjectI/D polymorphismen_UK
dc.subjectphysical performanceen_UK
dc.subjecthaplotypeen_UK
dc.subjectadolescentsen_UK
dc.subjectcaucasiansen_UK
dc.titleThe associations of ACE polymorphisms with physical, physiological and skill parameters in adolescentsen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1038/sj.ejhg.5201550-
dc.citation.jtitleEuropean Journal of Human Genetics-
dc.citation.issn1018-4813-
dc.citation.volume14-
dc.citation.issue3-
dc.citation.spage332-
dc.citation.epage339-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailcolin.moran@stir.ac.uk-
dc.contributor.affiliationSport-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Thessaly-
dc.contributor.affiliationUniversity of Thessaly-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity College London-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000235499300014-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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