Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12949
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dc.contributor.authorMoran, Colin Neil-
dc.contributor.authorYang, Nan-
dc.contributor.authorBailey, Mark E S-
dc.contributor.authorTsiokanos, Athanasios-
dc.contributor.authorJamurtas, Athanasios Z-
dc.contributor.authorMacArthur, Daniel G-
dc.contributor.authorNorth, Kathryn-
dc.contributor.authorPitsiladis, Yannis P-
dc.contributor.authorWilson, Richard H-
dc.date.accessioned2016-10-20T04:33:03Z-
dc.date.issued2007-01-
dc.identifier.urihttp://hdl.handle.net/1893/12949-
dc.description.abstractThe functional allele (577R) of ACTN3, which encodes human-actinin-3, has been reported to be associated with elite athletic status and with response to resistance training, while the nonfunctional allele (577X) has been proposed as a candidate metabolically thrifty allele. In a study of 992 adolescent Greeks, we show that there is a significant association (P=0.003) between the ACTN3 R577X polymorphism and 40 m sprint time in males that accounts for 2.3% of phenotypic variance, with the 577R allele contributing to faster times in an additive manner. The R577X polymorphism is not associated with other power phenotypes related to 40 m sprint, nor with an endurance phenotype. Furthermore, the polymorphism is not associated with obesity-related phenotypes in our population, suggesting that the 577X allele is not a thrifty allele, and thus the persistence of this null allele must be explained in other terms.en_UK
dc.language.isoen-
dc.publisherNature Publishing Group-
dc.relationMoran CN, Yang N, Bailey MES, Tsiokanos A, Jamurtas AZ, MacArthur DG, North K, Pitsiladis YP & Wilson RH (2007) Association analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeks, European Journal of Human Genetics, 15 (1), pp. 88-93.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectobesityen_UK
dc.subjectsprintingen_UK
dc.subjectCaucasiansen_UK
dc.subjectthrifty geneen_UK
dc.titleAssociation analysis of the ACTN3 R577X polymorphism and complex quantitative body composition and performance phenotypes in adolescent Greeksen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1038/sj.ejhg.5201724-
dc.citation.jtitleEuropean Journal of Human Genetics-
dc.citation.issn1018-4813-
dc.citation.volume15-
dc.citation.issue1-
dc.citation.spage88-
dc.citation.epage93-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailcolin.moran@stir.ac.uk-
dc.contributor.affiliationSport-
dc.contributor.affiliationUniversity of Sydney-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Thessaly-
dc.contributor.affiliationUniversity of Thessaly-
dc.contributor.affiliationUniversity of Sydney-
dc.contributor.affiliationUniversity of Sydney-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000242890600014-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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