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dc.contributor.authorScott, Robert A-
dc.contributor.authorBailey, Mark E S-
dc.contributor.authorMoran, Colin Neil-
dc.contributor.authorWilson, Richard H-
dc.contributor.authorFuku, Noriyuki-
dc.contributor.authorTanaka, Masashi-
dc.contributor.authorTsiokanos, Athanasios-
dc.contributor.authorJamurtas, Athanasios Z-
dc.contributor.authorGrammatikaki, Evangelia-
dc.contributor.authorMoschonis, George-
dc.contributor.authorManios, Yannis-
dc.contributor.authorPitsiladis, Yannis P-
dc.description.abstractStudies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk. Studies of the interaction between genetic and environmental factors such as physical activity (PA) will promote the understanding of how lifestyle can modulate genetic contributions to obesity. In this study, we investigated the effect of FTO genotype, and interactions with PA or energy intake, in young children and adolescents. In all, 1–5-year-old children from the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS) study (N=1980) and 11–18-year-old Greek adolescents (N=949) were measured for adiposity-related phenotypes and genotyped at the FTO single-nucleotide polymorphism (SNP) marker, rs17817449. Adolescents were classified as physically active or inactive based on self-reported levels of PA. In adolescents, FTO genotype influenced weight (P=0.001) and BMI (P=0.007). There was also a significant SNP*PA*gender interaction (P=0.028) on BMI, which reflected the association between FTO genotype and BMI in males (P=0.016), but not females (P=0.15), and significant SNP*PA interaction in males (P=0.007), but not females (P=0.74). The FTO genotype effect was more pronounced in inactive than active males. Inactive males homozygous for the G allele had a mean BMI 3 kg/m2 higher than T carriers (P=0.008). In the GENESIS study, no significant association between FTO genotype and adiposity was found. The present findings highlight PA as an important factor modifying the effect of FTO genotype.en_UK
dc.publisherEuropean Society of Human Genetics-
dc.relationScott RA, Bailey MES, Moran CN, Wilson RH, Fuku N, Tanaka M, Tsiokanos A, Jamurtas AZ, Grammatikaki E, Moschonis G, Manios Y & Pitsiladis YP (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males, European Journal of Human Genetics, 18 (12), pp. 1339-1343.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectphysical activityen_UK
dc.titleFTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent malesen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleEuropean Journal of Human Genetics-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationUniversity of Glasgow-
dc.contributor.affiliationTokyo Metropolitan Institute of Gerontology-
dc.contributor.affiliationTokyo Metropolitan Institute of Gerontology-
dc.contributor.affiliationUniversity of Thessaly-
dc.contributor.affiliationUniversity of Thessaly-
dc.contributor.affiliationHarokopio University-
dc.contributor.affiliationHarokopio University-
dc.contributor.affiliationHarokopio University-
dc.contributor.affiliationUniversity of Glasgow-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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