Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12939
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dc.contributor.authorMalcolm, Carien_UK
dc.contributor.authorHamilton, Ruthen_UK
dc.contributor.authorMcCulloch, Daphne Len_UK
dc.contributor.authorMontgomery, Coletteen_UK
dc.contributor.authorWeaver, Lawrence Ten_UK
dc.date.accessioned2014-09-13T13:32:53Z-
dc.date.available2014-09-13T13:32:53Zen_UK
dc.date.issued2003-08en_UK
dc.identifier.urihttp://hdl.handle.net/1893/12939-
dc.description.abstractPURPOSE. To test the hypothesis that the supplementation of the diets of pregnant women with a fish oil rich in docosahexaenoic acid (DHA) enhances retinal development in their healthy term infants, as measured during the early postnatal period by the electroretinogram (ERG).METHODS. One hundred pregnant women were randomized to receive either a fish oil (n = 50) or a placebo oleic acid dietary supplement (n = 50) from 15 weeks of pregnancy until delivery. Total fatty acids in red blood cells (RBCs) and plasma were measured in mothers at 15 and 28 weeks of pregnancy and at delivery and in their infants in umbilical cord blood. Infant retinal development was assessed within the first week of life with full-field ERGs that included a scotopic blue intensity series (n = 41) and a bright white flash (2.0 log cd-s/m2; n = 44).RESULTS. Infants born of mothers who received supplements did not differ at birth in weight, gestational age, or any other standard variable. Infant DHA status at birth, as measured from umbilical cord blood, did not differ significantly between maternal supplementation groups. ERG implicit times, amplitudes, and parameters of the stimulus-response function did not differ significantly between infants in the maternal supplemented and placebo groups. There was, however, a relationship between infant DHA status and maturity of the retina at birth, regardless of maternal supplementation group. A measure of retinal sensitivity (log sigma) correlated significantly (P less than 0.005) with DHA status (as a percentage of total fatty acid; TFA) in infant cord blood. Infants in the highest quartile for cord blood DHA had higher retinal sensitivity compared with infants in the lowest quartile. Infants in the highest quartile for plasma DHA, both as a percentage of TFA and concentration, were born at a significantly later gestational age than were infants in the lower quartiles.CONCLUSIONS. These findings demonstrate an association between the DHA status of term infants and retinal sensitivity, suggesting an essential role of this long-chain polyunsaturated fatty acid (LCPUFA) in the development and function of the retina. However, maternal DHA status was not significantly associated with infant retinal sensitivity and no direct effect of maternal supplementation was observed.en_UK
dc.language.isoenen_UK
dc.publisherAssociation for Research in Vision and Ophthalmologyen_UK
dc.relationMalcolm C, Hamilton R, McCulloch DL, Montgomery C & Weaver LT (2003) Scotopic Electroretinogram in Term Infants Born of Mothers Supplemented with Docosahexaenoic Acid during Pregnancy. Investigative Ophthalmology and Visual Science, 44 (8), pp. 3685-3691. https://doi.org/10.1167/iovs.02-0767en_UK
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.titleScotopic Electroretinogram in Term Infants Born of Mothers Supplemented with Docosahexaenoic Acid during Pregnancyen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-01-01en_UK
dc.rights.embargoreason[Malcolm_2003_Scotopic_Electroretinogram_in_Term_Infants.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.doi10.1167/iovs.02-0767en_UK
dc.citation.jtitleInvestigative Ophthalmology & Visual Scienceen_UK
dc.citation.issn1552-5783en_UK
dc.citation.issn0146-0404en_UK
dc.citation.volume44en_UK
dc.citation.issue8en_UK
dc.citation.spage3685en_UK
dc.citation.epage3691en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailcari.malcolm@stir.ac.uken_UK
dc.contributor.affiliationHealth Sciences Research - Stirling - LEGACYen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationGlasgow Caledonian Universityen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.contributor.affiliationUniversity of Glasgowen_UK
dc.identifier.isiWOS:000184383500058en_UK
dc.identifier.scopusid2-s2.0-0041842688en_UK
dc.identifier.wtid750297en_UK
dcterms.dateAccepted2003-08-31en_UK
dc.date.filedepositdate2013-05-15en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorMalcolm, Cari|en_UK
local.rioxx.authorHamilton, Ruth|en_UK
local.rioxx.authorMcCulloch, Daphne L|en_UK
local.rioxx.authorMontgomery, Colette|en_UK
local.rioxx.authorWeaver, Lawrence T|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-01-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameMalcolm_2003_Scotopic_Electroretinogram_in_Term_Infants.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source0146-0404en_UK
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