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Appears in Collections:Management, Work and Organisation Journal Articles
Peer Review Status: Refereed
Title: The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study
Author(s): Daly, Michael
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Keywords: Depression
C-reactive protein
Issue Date: Feb-2013
Date Deposited: 13-May-2013
Citation: Daly M (2013) The relationship of C-reactive protein to obesity-related depressive symptoms: a longitudinal study. Obesity, 21 (2), pp. 248-250.
Abstract: Obesity has been shown to produce a state of systematic low-grade inflammation that may have detrimental neuropsychiatric effects. This study examined longitudinal associations between obesity, inflammation, and depressive symptoms amongst a cohort of older English adults over 4 years of follow-up. Participants were 3891 obese and non-obese people drawn from the English Longitudinal Study of Ageing (ELSA) [aged 64.9 (SD = 8.8) years, 44.6% men]. Depressive symptoms were assessed at baseline and after 4 years of follow-up using the eight-item Centre for Epidemiological Studies - Depression Scale (CES-D). Approximately 26.3% (N = 1 025) of the sample were categorized as obese at baseline. Obesity at baseline was associated with elevated levels of depressive symptoms at follow-up (P less than .001), in analyses that adjusted for depression levels at baseline and sociodemographic and background variables including the prevalence of permanent illness/disability, alcohol consumption, sedentary behavior, and smoking. In addition, C-reactive protein (CRP) concentrations at baseline were independently associated with CES-D depression scores at follow-up (P = .008) in fully adjusted analyses. Subsequent mediation analyses revealed that CRP levels explained approximately 20% of the obesity-related longitudinal change in depression scores. These data suggest that chronic inflammation may be a key determinant of depressive symptoms in obesity.
DOI Link: 10.1002/oby.20051
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