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dc.contributor.authorWalshe, Ian-
dc.contributor.authorRobson-Ansley, Paula-
dc.contributor.authorGibson, Alan St Clair-
dc.contributor.authorLawrence, Claire-
dc.contributor.authorThompson, Kevin G-
dc.contributor.authorAnsley, Les-
dc.description.abstractInterleukin-6 (IL-6) is a cytokine that can mediate numerous biological actions including fatigue. Circulating IL-6 increases during prolonged exercise, and furthermore, the signalling receptors sIL-6R and sgp130 are also increased. The variability of the response of these markers to exercise is unknown; therefore, we examined the changes in these markers to a preloaded time trial bout of running. Nine males performed three identical trials where participants ran at 60% for 2 h interspersed with 30 s at 90% TeX every 10 min, followed by a 5-km time trial. Blood samples were drawn at baseline, following the 2-h bout, post time trial, 1 h post time trial and the following morning. Results showed that between-subject variability (CVg) was greater than within-subject variation (CVi) for the three markers. IL-6, sIL-6R and sgp130 demonstrated a CVi of 15.3-25.5%, 15.0-17.6% and 6.2-9.4% variation, respectively, across the time points. When the data from the second and third trials were analysed independently, CVi was reduced which is supported by the time trial results for which CVi improve (4.7-2.4%). In conclusion, the results indicate that a large variation in response to exercise can be reduced following a habituation trial.en_UK
dc.relationWalshe I, Robson-Ansley P, Gibson ASC, Lawrence C, Thompson KG & Ansley L (2010) The reliability of the IL-6, sIL-6R and sgp130 response to a preloaded time trial, European Journal of Applied Physiology, 110 (3), pp. 619-625.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectTime trialen_UK
dc.subject.lcshCarbohydrates -Analysis-
dc.subject.lcshFatigue Case studies-
dc.titleThe reliability of the IL-6, sIL-6R and sgp130 response to a preloaded time trialen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleEuropean Journal of Applied Physiology-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationNorthumbria University-
dc.contributor.affiliationNorthumbria University-
dc.contributor.affiliationNorthumbria University-
dc.contributor.affiliationNorthumbria University-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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