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dc.contributor.authorRobins, James B-
dc.contributor.authorWoodward, Mark-
dc.contributor.authorLowe, Gordon D-
dc.contributor.authorMcCaul, Pamela-
dc.contributor.authorCheyne, Helen-
dc.contributor.authorWalker, James Johnston-
dc.description.abstractThis study evaluates the relationship between the first trimester assessment of maternal rheology and the subsequent development of pregnancy induced hypertension. This is a prospective observational study based in the Glasgow Royal Maternity Hospital, Scotland. From an original population of 744 consecutive antenatal attendees a total of 579 women were booked at less than 14 weeks' gestation. The main study group is a further subset comprising 251 primigravid women booking with a singleton pregnancy without essential hypertension. Previously published data from a group of non-pregnant women of similar age drawn from the same local community was used for external comparison. Blood samples were collected at the booking visit, from which fibrinogen, red cell aggregation, haematocrit and plasma, whole blood, relative and corrected viscosities were recorded. Information was obtained from the case notes in retrospect starting approximately 1 year after the first patients had first been recruited into the trial. The overall outcome of the pregnancies was noted with particular reference to pregnancy induced hypertension (PIH), birth weight, antepartum haemorrhage, pre-term labour, perinatal death, condition at delivery and neonatal complication. Our results show PIH is associated with a significantly raised mean blood viscosity and fibrinogen at time of booking. All significance disappears after adjustment for smoking, diastolic blood pressure and age. Viscosity is, however, only marginally non-significant (p=0.07). In conclusion, blood rheology, in particular blood viscosity and fibrinogen, may play a predictive role in the development of pregnancy-induced hypertension. When combined with measurement of smoking and diastolic blood pressure at booking, these measurements could be used to calculate a risk score for the development of PIH, allowing targeting of antenatal care. Further data is required.en_UK
dc.publisherInforma Healthcare-
dc.relationRobins JB, Woodward M, Lowe GD, McCaul P, Cheyne H & Walker JJ (2005) First trimester maternal blood rheology and pregnancy induced hypertension, Journal of Obstetrics and Gynaecology, 25 (8), pp. 746-750.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.titleFirst trimester maternal blood rheology and pregnancy induced hypertensionen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.citation.jtitleJournal of Obstetrics and Gynaecology-
dc.type.statusPublisher version (final published refereed version)-
dc.contributor.affiliationGlasgow Royal Maternity Hospital-
dc.contributor.affiliationGlasgow Royal Maternity Hospital-
dc.contributor.affiliationGlasgow Royal Maternity Hospital-
dc.contributor.affiliationGlasgow Royal Maternity Hospital-
dc.contributor.affiliationNMAHP Research-
dc.contributor.affiliationGlasgow Royal Maternity Hospital-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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