Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12724
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dc.contributor.authorRobson-Ansley, Paulaen_UK
dc.contributor.authorCockburn, Emmaen_UK
dc.contributor.authorWalshe, Ianen_UK
dc.contributor.authorStevenson, Emma Jen_UK
dc.contributor.authorNimmo, Myra Aen_UK
dc.date.accessioned2016-08-29T23:37:46Z-
dc.date.available2016-08-29T23:37:46Zen_UK
dc.date.issued2010en_UK
dc.identifier.urihttp://hdl.handle.net/1893/12724-
dc.description.abstractThe aim of this article is to review current literature on the response of soluble interleukin-6 receptor to exercise and identify a potential role for sIL-6R in skeletal muscle function. We also provide novel data on the impact of eccentric exercise on circulating levels. The aim of the research study was to investigate changes in plasma concentration of soluble interleukin-6 receptor (sIL-6R) and soluble glycoprotein 130 (sgp130) during recovery from exercise-induced muscle damage (EIMD) up to 72 h and their relationship with delayed onset muscle soreness (DOMS) and muscle function. 18 participants attended the laboratory on 4 consecutive days. On the first day, participants completed 6 sets of 10 repetitions of unilateral eccentric-concentric knee flexions at a test speed of 1.05 rad.s(-1) using a Cybex Isokentic dynamometer to induce muscle damage of the hamstrings. Prior to the eccentric exercise bout and each subsequent morning, following an overnight fast, participants had a venous blood sample taken which was centrifuged immediately and plasma frozen at -80 degrees C until later analysis. Plasma IL-6 and sgp130 were unchanged at any time point during recovery but sIL-6R was significantly reduced at 48 h and 72 h post-exercise (p less than 0.05). Plasma sIL-6R was correlated with DOMS at 48 h post EIMD (r = 0.45, p less than 0.05) and peak muscle torque at 24 h and 48 h following EIMD (r = -.42; p less than 0.05; r = -.57; p less than 0.01 respectively). Our novel finding that sIL-6R concentrations are decreased 2-3 days following a single bout of EIMD may reflect a regulatory mechanism controlling the influx of different leukocyte subpopulations into damaged tissue, although this needs to be confirmed by future studies. Our data suggests an association between sIL-6R, perception of pain and reduced peak muscle performance post-EIMD but further investigation is warranted to explore this relationship and implications for exercise performance.en_UK
dc.language.isoenen_UK
dc.publisherAssociation for the Advancement of Sports Medicineen_UK
dc.relationRobson-Ansley P, Cockburn E, Walshe I, Stevenson EJ & Nimmo MA (2010) The effect of exercise on plasma soluble IL-6 receptor concentration: A dichotomous response. Exercise Immunology Review, 16, pp. 56-76.en_UK
dc.rightsThe publisher has not responded to our queries therefore this work cannot be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.rights.urihttp://www.rioxx.net/licenses/under-embargo-all-rights-reserveden_UK
dc.subjectInterleukin-6en_UK
dc.subjectsoluble interleukin-6 receptoren_UK
dc.subjectsIL-6Ren_UK
dc.subjectglycoprotein 130en_UK
dc.subjectDOMSen_UK
dc.subjecteccentric exerciseen_UK
dc.subjectStriated muscle Physiologyen_UK
dc.subjectMusculoskeletal system Physiologyen_UK
dc.titleThe effect of exercise on plasma soluble IL-6 receptor concentration: A dichotomous responseen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate3000-12-01en_UK
dc.rights.embargoreason[The effect of exercise on plasma soluble IL-6.pdf] The publisher has not responded to our queries. This work cannot be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.identifier.pmid20839491en_UK
dc.citation.jtitleExercise Immunology Reviewen_UK
dc.citation.issn1077-5552en_UK
dc.citation.volume16en_UK
dc.citation.spage56en_UK
dc.citation.epage76en_UK
dc.citation.publicationstatusPublisheden_UK
dc.citation.peerreviewedRefereeden_UK
dc.type.statusVoR - Version of Recorden_UK
dc.author.emailian.walshe@stir.ac.uken_UK
dc.contributor.affiliationNorthumbria Universityen_UK
dc.contributor.affiliationNorthumbria Universityen_UK
dc.contributor.affiliationSporten_UK
dc.contributor.affiliationNorthumbria Universityen_UK
dc.contributor.affiliationUniversity of Strathclydeen_UK
dc.identifier.isiWOS:000281534300005en_UK
dc.identifier.scopusid2-s2.0-77957958068en_UK
dc.identifier.wtid708300en_UK
dcterms.dateAccepted2010-12-31en_UK
dc.date.filedepositdate2013-05-08en_UK
rioxxterms.typeJournal Article/Reviewen_UK
rioxxterms.versionVoRen_UK
local.rioxx.authorRobson-Ansley, Paula|en_UK
local.rioxx.authorCockburn, Emma|en_UK
local.rioxx.authorWalshe, Ian|en_UK
local.rioxx.authorStevenson, Emma J|en_UK
local.rioxx.authorNimmo, Myra A|en_UK
local.rioxx.projectInternal Project|University of Stirling|https://isni.org/isni/0000000122484331en_UK
local.rioxx.freetoreaddate3000-12-01en_UK
local.rioxx.licencehttp://www.rioxx.net/licenses/under-embargo-all-rights-reserved||en_UK
local.rioxx.filenameThe effect of exercise on plasma soluble IL-6.pdfen_UK
local.rioxx.filecount1en_UK
local.rioxx.source1077-5552en_UK
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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