Please use this identifier to cite or link to this item:
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles
Peer Review Status: Refereed
Title: Testosterone administration to older men improves muscle function: molecular and physiological mechanisms
Author(s): Ferrando, Arny A
Sheffield-Moore, Melinda
Yeckel, Catherine W
Gilkison, Charles R
Jiang, Jie
Achacosa, Alison
Lieberman, Steven A
Tipton, Kevin
Wolfe, Robert R
Urban, Randall J
Contact Email:
Keywords: Aging
Insulin-like growth factor I
Lean body mass
Muscle strength
Testosterone therapeutic use
Testosterone physiology
Issue Date: Mar-2002
Date Deposited: 1-May-2013
Citation: Ferrando AA, Sheffield-Moore M, Yeckel CW, Gilkison CR, Jiang J, Achacosa A, Lieberman SA, Tipton K, Wolfe RR & Urban RJ (2002) Testosterone administration to older men improves muscle function: molecular and physiological mechanisms. American Journal of Physiology - Endocrinology and Metabolism, 282 (3), pp. E601-E607.
Abstract: We investigated the effects of 6 mo of near-physiological testosterone administration to older men on skeletal muscle function and muscle protein metabolism. Twelve older men (≥60 yr) with serum total testosterone concentrations less than 17 nmol/l (480 ng/dl) were randomly assigned in double-blind manner to receive either placebo (n = 5) or testosterone enanthate (TE; n = 7) injections. Weekly intramuscular injections were given for the 1st mo to establish increased blood testosterone concentrations at 1 mo and then changed to biweekly injections until the 6-mo time point. TE doses were adjusted to maintain nadir serum testosterone concentrations between 17 and 28 nmol/l. Lean body mass (LBM), muscle volume, prostate size, and urinary flow were measured at baseline and at 6 mo. Protein expression of androgen receptor (AR) and insulin-like growth factor I, along with muscle strength and muscle protein metabolism, were measured at baseline and at 1 and 6 mo of treatment. Hematological parameters were followed monthly throughout the study. Older men receiving testosterone increased total and leg LBM, muscle volume, and leg and arm muscle strength after 6 mo. LBM accretion resulted from an increase in muscle protein net balance, due to a decrease in muscle protein breakdown. TE treatment increased expression of AR protein at 1 mo, but expression returned to pre-TE treatment levels by 6 mo. IGF-I protein expression increased at 1 mo and remained increased throughout TE administration. We conclude that physiological and near-physiological increases of testosterone in older men will increase muscle protein anabolism and muscle strength.
DOI Link: 10.1152/ajpendo.00362.2001
Rights: The publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.
Licence URL(s):

Files in This Item:
File Description SizeFormat 
Tipton_2002_Testosterone_administration_to_older_men.pdfFulltext - Published Version114.32 kBAdobe PDFUnder Embargo until 2999-12-14    Request a copy

Note: If any of the files in this item are currently embargoed, you can request a copy directly from the author by clicking the padlock icon above. However, this facility is dependent on the depositor still being contactable at their original email address.

This item is protected by original copyright

Items in the Repository are protected by copyright, with all rights reserved, unless otherwise indicated.

The metadata of the records in the Repository are available under the CC0 public domain dedication: No Rights Reserved

If you believe that any material held in STORRE infringes copyright, please contact providing details and we will remove the Work from public display in STORRE and investigate your claim.