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dc.contributor.authorBurke, Louise Men_UK
dc.contributor.authorHawley, John Aen_UK
dc.contributor.authorRoss, Megan Len_UK
dc.contributor.authorMoore, Daniel Ren_UK
dc.contributor.authorPhillips, Stuart Men_UK
dc.contributor.authorSlater, Gary Ren_UK
dc.contributor.authorStellingwerff, Trenten_UK
dc.contributor.authorTipton, Kevinen_UK
dc.contributor.authorGarnham, Andrew Pen_UK
dc.contributor.authorCoffey, Vernon Gen_UK
dc.description.abstractPurpose: We have previously shown that the aminoacidemia caused by the consumption of a rapidly digested protein after resistance exercise enhances muscle protein synthesis (MPS) more than the amino acid (AA) profile associated with a slowly digested protein. Here, we investigated whether differential feeding patterns of a whey protein mixture commencing before exercise affect postexercise intracellular signaling and MPS. Methods: Twelve resistance-trained males performed leg resistance exercise 45 min after commencing each of three volume-matched nutrition protocols: placebo (PLAC, artificially sweetened water), BOLUS (25 g of whey protein + 5 g of leucine dissolved in artificially sweetened water; 1× 500 mL), or PULSE (15× 33-mL aliquots of BOLUS drink every 15 min). Results: The preexercise rise in plasma AA concentration with PULSE was attenuated compared with BOLUS (P less than 0.05); this effect was reversed after exercise, with two-fold greater leucine concentrations in PULSE compared with BOLUS (P less than 0.05). One-hour postexercise, phosphorylation of p70 S6Kthr389 and rpS6ser235/6 was increased above baseline with BOLUS and PULSE, but not PLAC (P less than 0.05); furthermore, PULSE greater than BOLUS (P less than 0.05). MPS throughout 5 h of recovery was higher with protein ingestion compared with PLAC (0.037 ± 0.007), with no differences between BOLUS or PULSE (0.085 ± 0.013 vs. 0.095 ± 0.010%·h-1, respectively, P = 0.56). Conclusions: Manipulation of aminoacidemia before resistance exercise via different patterns of intake of protein altered plasma AA profiles and postexercise intracellular signaling. However, there was no difference in the enhancement of the muscle protein synthetic response after exercise. Protein sources producing a slow AA release, when consumed before resistance exercise in sufficient amounts, are as effective as rapidly digested proteins in promoting postexercise MPS.en_UK
dc.publisherAmerican College of Sports Medicine / Lippincott, Williams & Wilkinsen_UK
dc.relationBurke LM, Hawley JA, Ross ML, Moore DR, Phillips SM, Slater GR, Stellingwerff T, Tipton K, Garnham AP & Coffey VG (2012) Preexercise aminoacidemia and muscle protein synthesis after resistance exercise. Medicine and Science in Sports and Exercise, 44 (10), pp. 1968-1977.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectAmino acid deliveryen_UK
dc.subjectfast and slow proteinsen_UK
dc.subjectmuscle protein synthesisen_UK
dc.subjectFatigue Case studiesen_UK
dc.subjectNutrient interactionsen_UK
dc.subjectMineral metabolismen_UK
dc.subjectNutrition Physiologyen_UK
dc.subjectMetabolism physiology.en_UK
dc.titlePreexercise aminoacidemia and muscle protein synthesis after resistance exerciseen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Tipton_2012_Preexercise_Aminoacidemia.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleMedicine and Science in Sports and Exerciseen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationAustralian Institute of Sporten_UK
dc.contributor.affiliationRMIT Universityen_UK
dc.contributor.affiliationAustralian Institute of Sporten_UK
dc.contributor.affiliationMcMaster Universityen_UK
dc.contributor.affiliationMcMaster Universityen_UK
dc.contributor.affiliationAustralian Institute of Sporten_UK
dc.contributor.affiliationNestle Research Centeren_UK
dc.contributor.affiliationDeakin Universityen_UK
dc.contributor.affiliationRMIT Universityen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorBurke, Louise M|en_UK
local.rioxx.authorHawley, John A|en_UK
local.rioxx.authorRoss, Megan L|en_UK
local.rioxx.authorMoore, Daniel R|en_UK
local.rioxx.authorPhillips, Stuart M|en_UK
local.rioxx.authorSlater, Gary R|en_UK
local.rioxx.authorStellingwerff, Trent|en_UK
local.rioxx.authorTipton, Kevin|0000-0002-6545-8122en_UK
local.rioxx.authorGarnham, Andrew P|en_UK
local.rioxx.authorCoffey, Vernon G|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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