Please use this identifier to cite or link to this item: http://hdl.handle.net/1893/12470
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dc.contributor.authorBurke, Louise M-
dc.contributor.authorHawley, John A-
dc.contributor.authorRoss, Megan L-
dc.contributor.authorMoore, Daniel R-
dc.contributor.authorPhillips, Stuart M-
dc.contributor.authorSlater, Gary R-
dc.contributor.authorStellingwerff, Trent-
dc.contributor.authorTipton, Kevin-
dc.contributor.authorGarnham, Andrew P-
dc.contributor.authorCoffey, Vernon G-
dc.date.accessioned2016-08-29T20:48:18Z-
dc.date.issued2012-10-
dc.identifier.urihttp://hdl.handle.net/1893/12470-
dc.description.abstractPurpose: We have previously shown that the aminoacidemia caused by the consumption of a rapidly digested protein after resistance exercise enhances muscle protein synthesis (MPS) more than the amino acid (AA) profile associated with a slowly digested protein. Here, we investigated whether differential feeding patterns of a whey protein mixture commencing before exercise affect postexercise intracellular signaling and MPS. Methods: Twelve resistance-trained males performed leg resistance exercise 45 min after commencing each of three volume-matched nutrition protocols: placebo (PLAC, artificially sweetened water), BOLUS (25 g of whey protein + 5 g of leucine dissolved in artificially sweetened water; 1× 500 mL), or PULSE (15× 33-mL aliquots of BOLUS drink every 15 min). Results: The preexercise rise in plasma AA concentration with PULSE was attenuated compared with BOLUS (P less than 0.05); this effect was reversed after exercise, with two-fold greater leucine concentrations in PULSE compared with BOLUS (P less than 0.05). One-hour postexercise, phosphorylation of p70 S6Kthr389 and rpS6ser235/6 was increased above baseline with BOLUS and PULSE, but not PLAC (P less than 0.05); furthermore, PULSE greater than BOLUS (P less than 0.05). MPS throughout 5 h of recovery was higher with protein ingestion compared with PLAC (0.037 ± 0.007), with no differences between BOLUS or PULSE (0.085 ± 0.013 vs. 0.095 ± 0.010%·h-1, respectively, P = 0.56). Conclusions: Manipulation of aminoacidemia before resistance exercise via different patterns of intake of protein altered plasma AA profiles and postexercise intracellular signaling. However, there was no difference in the enhancement of the muscle protein synthetic response after exercise. Protein sources producing a slow AA release, when consumed before resistance exercise in sufficient amounts, are as effective as rapidly digested proteins in promoting postexercise MPS.en_UK
dc.language.isoen-
dc.publisherAmerican College of Sports Medicine / Lippincott, Williams & Wilkins-
dc.relationBurke LM, Hawley JA, Ross ML, Moore DR, Phillips SM, Slater GR, Stellingwerff T, Tipton K, Garnham AP & Coffey VG (2012) Preexercise aminoacidemia and muscle protein synthesis after resistance exercise, Medicine and Science in Sports and Exercise, 44 (10), pp. 1968-1977.-
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author. You can only request a copy if you wish to use this work for your own research or private study.-
dc.subjectAmino acid deliveryen_UK
dc.subjectfast and slow proteinsen_UK
dc.subjectleucineen_UK
dc.subjectmuscle protein synthesisen_UK
dc.subject.lcshFatigue Case studies-
dc.subject.lcshNutrient interactions-
dc.subject.lcshMineral metabolism-
dc.subject.lcshNutrition Physiology-
dc.subject.lcshMetabolism physiology.-
dc.titlePreexercise aminoacidemia and muscle protein synthesis after resistance exerciseen_UK
dc.typeJournal Articleen_UK
dc.rights.embargodate2999-12-31T00:00:00Z-
dc.rights.embargoreasonThe publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.-
dc.identifier.doihttp://dx.doi.org/10.1249/MSS.0b013e31825d28fa-
dc.citation.jtitleMedicine and Science in Sports and Exercise-
dc.citation.issn0195-9131-
dc.citation.volume44-
dc.citation.issue10-
dc.citation.spage1968-
dc.citation.epage1977-
dc.citation.publicationstatusPublished-
dc.citation.peerreviewedRefereed-
dc.type.statusPublisher version (final published refereed version)-
dc.author.emailk.d.tipton@stir.ac.uk-
dc.contributor.affiliationAustralian Institute of Sport-
dc.contributor.affiliationRMIT University-
dc.contributor.affiliationAustralian Institute of Sport-
dc.contributor.affiliationMcMaster University-
dc.contributor.affiliationMcMaster University-
dc.contributor.affiliationAustralian Institute of Sport-
dc.contributor.affiliationNestle Research Center-
dc.contributor.affiliationSport-
dc.contributor.affiliationDeakin University-
dc.contributor.affiliationRMIT University-
dc.rights.embargoterms2999-12-31-
dc.rights.embargoliftdate2999-12-31-
dc.identifier.isi000309110700018-
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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