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dc.contributor.authorParente, Valeriaen_UK
dc.contributor.authorD’Antona, Giuseppeen_UK
dc.contributor.authorAdami, Raffaellaen_UK
dc.contributor.authorMiotti, Daniloen_UK
dc.contributor.authorCapodaglio, Paoloen_UK
dc.contributor.authorDe Vito, Giuseppeen_UK
dc.contributor.authorBottinelli, Robertoen_UK
dc.description.abstractFour elderly women (78 ± 4.3 years) were resistance trained (RT) for one year and needle biopsies of the vastus lateralis muscle were taken pre- and post-RT. A training intensity of 60% one-repetition maximum (1RM) was adopted for the entire duration of the study. Following RT, significant gain in isometric force of the quadriceps muscles was observed and MHC isoform distribution of vastus lateralis muscle showed a very significant shift from MHC-1 and MHC-2X towards MHC-2A, i.e. a bi-directional shift. A large population (n = 310) of individual skinned muscle fibres were dissected from biopsy samples and used for determination of cross-sectional area (CSA), specific force (Po/CSA) and unloaded shortening velocity (Vo) at 12°C and maximum activation. Fibres were classified on the basis of their MHC isoform content determined by SDS-PAGE in three pure fibre types (1, 2A and 2X) and two hybrid fibre types (1-2A and 2AX). Whereas the CSA of individual muscle fibres did not change, Po/CSA was significantly higher in both type 1 and type 2A fibres post training. Vo of type 1 fibres was significantly higher post-training, whereas no change in Vo was observed in type 2A fibres. The number of pure type 2X fibres was very low especially post-training and did not enable a statistically significant comparison. The data suggest that in elderly women moderate and prolonged RT: (1) can determine similar adaptations in MHC distribution of skeletal muscle to those expected in young subjects; (2) can improve function of muscle fibres.en_UK
dc.relationParente V, D’Antona G, Adami R, Miotti D, Capodaglio P, De Vito G & Bottinelli R (2008) Long-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly women. European Journal of Applied Physiology, 104 (5), pp. 885-893.
dc.rightsThe publisher does not allow this work to be made publicly available in this Repository. Please use the Request a Copy feature at the foot of the Repository record to request a copy directly from the author; you can only request a copy if you wish to use this work for your own research or private study.en_UK
dc.subjectExercise trainingen_UK
dc.subjectSkinned fibresen_UK
dc.subjectMyosin isoformsen_UK
dc.subjectMuscle strengthen_UK
dc.subjectExercise for older peopleen_UK
dc.subjectPhysical fitness Physiological aspectsen_UK
dc.titleLong-term resistance training improves force and unloaded shortening velocity of single muscle fibres of elderly womenen_UK
dc.typeJournal Articleen_UK
dc.rights.embargoreason[Parente-etal-EJAP-2008.pdf] The publisher does not allow this work to be made publicly available in this Repository therefore there is an embargo on the full text of the work.en_UK
dc.citation.jtitleEuropean Journal of Applied Physiologyen_UK
dc.type.statusVoR - Version of Recorden_UK
dc.contributor.affiliationUniversity of Paviaen_UK
dc.contributor.affiliationUniversity of Paviaen_UK
dc.contributor.affiliationUniversity of Paviaen_UK
dc.contributor.affiliationFondazione Salvatore Maugeri (IRCCS)en_UK
dc.contributor.affiliationOspedale San Giuseppe, Italyen_UK
dc.contributor.affiliationUniversity of Paviaen_UK
rioxxterms.typeJournal Article/Reviewen_UK
local.rioxx.authorParente, Valeria|en_UK
local.rioxx.authorD’Antona, Giuseppe|en_UK
local.rioxx.authorAdami, Raffaella|en_UK
local.rioxx.authorMiotti, Danilo|en_UK
local.rioxx.authorCapodaglio, Paolo|en_UK
local.rioxx.authorDe Vito, Giuseppe|en_UK
local.rioxx.authorBottinelli, Roberto|en_UK
local.rioxx.projectInternal Project|University of Stirling|
Appears in Collections:Faculty of Health Sciences and Sport Journal Articles

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